Effect of miR-146a/bFGF/PEG-PEI Nanoparticles on Inflammation Response and Tissue Regeneration of Human Dental Pulp Cells

Figure 3

Drug release profile and cell proliferation of DPCs with LPS treatment. (a) The in vitro drug release experiment showed that the drug release of bFGF, miR-146a, and miR-146a/bFGF amounted to more than 70% at the beginning of the 12 h and maintained slow release over 25 h. (b) CCK8 showed that, comparing with the control group, the OD value of LPS group significantly decreased at both 72 and 96 h after treatment (). Both miR-146a gel and bFGF gel groups did not show any significant difference (), albeit the OD value of miR-146a/bFGF gel group significantly increased at both 72 and 96 h after treatment ().

(a)

(b)