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BioMed Research International
Volume 2016, Article ID 3912175, 12 pages
Review Article

Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis

1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China
2Graduate School of Peking Union Medical College, Beijing, China
3National Research Institute for Family Planning, Beijing, China
4Centers for Disease Control and Prevention, Zhejiang, China
5Department of Cardiology, ZhongDa Hospital, Southeast University, Nanjing, Jiangsu, China

Received 16 August 2016; Accepted 9 October 2016

Academic Editor: Hai-Feng Pan

Copyright © 2016 Min Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Apo E genes involved in lipoprotein synthesis and metabolism are considered one of the candidates to CHD. However, the results remain conflicting. Methods. We performed this meta-analysis based on 30 published studies including 11,804 CHD patients and 17,713 controls. Results. Compared with the wild genotype E3/3, the variant genotypes ApoEE3/4 and E4/4 were associated with 22% and 45% increased risk of CHD, respectively (E3/4 versus E3/3: OR = 1.22, 95% CI = 1.15–1.29; E4/4 versus E3/3: OR = 1.45, 95% CI = 1.23–1.71). Besides, compared with ε3 allele, carriers with the ε4 allele had a 46% increased risk of CHD (OR = 1.46, 95% CI = 1.28–1.66), while the ε2 had no significantly decreased risk of CHD. In the subgroup analysis by ethnicity, ε4 had a 25% increased risk of CHD in Caucasians (OR = 1.25, 95% CI = 1.11–1.41), and the effects were more evident in Mongolians (OR = 2.29, 95% CI = 1.89–2.77). The ε2 allele had a decreased risk of CHD in Caucasians (OR = 0.84, 95% CI = 0.74–0.96), but not in Mongolians. Conclusions. The analysis suggested that ApoEε4 mutation was associated with the increased risk of CHD, while ApoEε2 allele had a decreased risk of CHD just in Caucasians.