Review Article
Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis
Table 2
Distribution of Apo E alleles in the case and control groups included in the meta-analysis.
| | First author (year) | Case/control (N/N) | Distribution of apolipoprotein E alleles | | ε2 | ε3 | ε4 | | Case | Control | Case | Control | Case | Control | | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) |
| | (1) Wang (2004) | 292/680 | 21 (7.2) | 48 (7.1) | 232 (79.4) | 583 (85.7) | 39 (13.4) | 49 (7.2) | | (2) Bai (2001) | 100/94 | 4 (4.0) | 5 (5.3) | 90 (90.0) | 86 (91.5) | 6 (6.0) | 3 (3.2) | | (3) Wang (2004) | 372/700 | 27 (7.3) | 50 (7.1) | 291 (78.2) | 601 (85.9) | 54 (14.5) | 49 (7.0) | | (4) Peng (2001) | 426/360 | 34 (8.0) | 30 (8.3) | 328 (77.0) | 303 (84.2) | 64 (15.0) | 27 (7.5) | | (5) Yang (2001) | 408/272 | 20 (4.9) | 15 (5.5) | 348 (85.3) | 239 (87.9) | 40 (9.8) | 18 (6.6) | | (6) Ouyang (2005) | 400/200 | 31 (7.7) | 18 (9.0) | 291 (72.8) | 167 (81.5) | 78 (19.5) | 19 (9.5) | | (7) Heide (2009) | 242/500 | 11 (4.5) | 36 (8.3) | 202 (83.5) | 406 (81.2) | 29 (12.0) | 58 (11.5) | | (8) Kolovou (2009) | 718/496 | 37 (5.2) | 39 (7.9) | 612 (85.2) | 414 (83.4) | 69 (9.6) | 43 (8.7) | | (9) Bahri (2008) | 160/200 | 6 (3.7) | 9 (4.5) | 140 (87.6) | 174 (87.0) | 14 (8.7) | 17 (8.5) | | (10) Akanji (2007) | 100/130 | 6 (6.0) | 9 (6.9) | 87 (87.0) | 108 (83.1) | 7 (7.0) | 13 (10.0) | | (11) Aydogan (2009) | 82/46 | 4 (4.9) | 4 (17.4) | 69 (84.1) | 37 (80.4) | 9 (11.0) | 5 (11.6) | | (12) Ranjith (2004) | 390/600 | 10 (2.6) | 27 (4.5) | 330 (84.6) | 517 (86.2) | 50 (12.8) | 56 (9.3) | | (13) Peng (2003) | 300/314 | 24 (8.0) | 16 (5.0) | 237 (79.0) | 275 (87.6) | 39 (13.0) | 23 (7.4) | | (14) Singh (2008) | 386/300 | 21 (5.4) | 23 (7.7) | 307 (79.5) | 257 (85.6) | 58 (15.1) | 20 (6.7) | | (15) Keavney (2003) | 8968/11514 | 609 (6.8) | 911 (7.9) | 6778 (75.6) | 8830 (76.7) | 1581 (17.6) | 1773 (15.4) | | (16) Freitas (2002) | 1280/1248 | 61 (4.8) | 90 (7.2) | 1002 (78.2) | 958 (76.8) | 217 (17.0) | 200 (16.0) | | (17) Kawakami (2001) | 450/426 | 13 (2.9) | 15 (3.5) | 390 (86.7) | 349 (81.9) | 47 (10.4) | 62 (14.6) | | (18) Attila (2001) | 214/184 | 26 (12.1) | 15 (8.1) | 166 (77.6) | 163 (88.6) | 22 (10.3) | 6 (3.3) | | (19) Kharrazi (2006) | 230/270 | 18 (7.8) | 11 (4.1) | 169 (73.5) | 250 (92.6) | 43 (18.7) | 9 (3.3) | | (20) Gamboa (2008) | 312/400 | 5 (1.6) | 9 (2.2) | 283 (90.7) | 364 (91.0) | 24 (7.7) | 27 (6.8) | | (21) Al-Yahyaee (2007) | 134/354 | 1 (0.7) | 6 (1.7) | 127 (94.8) | 335 (94.6) | 6 (4.5) | 13 (3.7) | | (22) Al-Bustan (2009) | 286/244 | 21 (7.4) | 23 (9.4) | 246 (86.0) | 207 (84.9) | 19 (6.6) | 14 (5.7) | | (23) Vaisi-Raygani (2010) | 324/357 | 31 (9.6) | 40 (11.3) | 257 (79.3) | 289 (80.8) | 36 (11.1) | 28 (7.9) | | (24) Corella (2011) | 1035/2246 | 42 (4.1) | 123 (5.5) | 891 (86.1) | 1928 (85.8) | 102 (9.9) | 195 (8.7) | | (25) Fallah (2011) | 380/400 | 73 (19.2) | 55 (13.8) | 141 (37.1) | 218 (54.5) | 166 (43.7) | 127 (31.8) | | (26) Gustavsson (2012) | 3470/9308 | 199 (5.7) | 738 (7.9) | 2672 (77.0) | 7065 (75.9) | 599 (17.3) | 1505 (16.2) | | (27) Heidari (2013) | 132/122 | 16 (12.1) | 14 (11.5) | 110 (83.3) | 108 (88.5) | 6 (4.5) | 0 (0) | | (28) Marrzoq (2011) | 138/136 | 5 (3.6) | 7 (5.2) | 114 (82.6) | 119 (87.5) | 19 (13.8) | 10 (7.4) | | (29) Afroze (2015) | 400/900 | 26 (6.5) | 66 (7.3) | 291 (72.8) | 732 (81.3) | 83 (20.8) | 102 (11.3) | | (30) Sapkota (2015) | 1446/2432 | 52 (3.6) | 95 (3.9) | 1285 (88.9) | 2174 (89.4) | 109 (7.5) | 163 (6.7) |
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