Comparison of Neuroprotective Effect of Bevacizumab and Sildenafil following Induction of Stroke in a Mouse Model

Figure 3

CD45 staining (red) of brains section of mice following MCAO induction without treatment (saline injected, controls) and perfusion with fluorescent gelatin (green). The nuclei are stained with DAPI (blue). (a) CD45 immunostaining (red) showing infiltration of the inflammatory cells to the injured hemisphere and increased cellularity (DAPI, blue) (5), while the unaffected hemisphere is well perfused (green). (b) Higher magnification of the injured versus unaffected brain (20). (c) Incomplete perfusion of the vessels in the infarct area, with extravasation of inflammatory cells to the tissue, as compared to the unaffected brain (green) without inflammatory cells. (d–f) Incomplete vascularization with intra- and extracellular inflammatory cells (40).

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