Comparison of Neuroprotective Effect of Bevacizumab and Sildenafil following Induction of Stroke in a Mouse Model

Table 2

Penumbra, stroke, and brain edema in sildenafil-, bevacizumab- (immediate and 6 h), and saline-treated MCAO induced mice.

Treatment		Mean penumbra area (mm^3)	Mean stroke area (mm^3)	Total stroke area (mm^3)	Total injured hemisphere (mm^3)	% of injured hemisphere	Normal hemisphere	Hemispheric asymmetry (ratio)
Sildenafil	16	5.7 ± 2.02	12.72 ± 6.76	18.42 ± 5.41	32.63 ± 1.60	56.10 ± 15.31	29.68 ± 3.13	1.099
Bevacizumab	19	7.3 ± 3.5	10.50 ± 5.53	17.79 ± 5.80	34.67 ± 2.04	51.0 ± 15.52	31.89 ± 3.25	1.086
	7	2.4 ± 2.0	7.40 ± 5.42	9.80 ± 8.00	32.90 ± 2.93	29.00 ± 22.3	33.51 ± 2.23	0.982
Saline	16	4.5 ± 2.03	14.70 ± 6.75	19.20 ± 6.38	32.72 ± 2.95	58.09 ± 16.7	30.70 ± 3.20	1.065

versus saline and versus sildenafil.