Comparison of Neuroprotective Effect of Bevacizumab and Sildenafil following Induction of Stroke in a Mouse Model

Table 3

Mortality and morbidity in treated rats after MCAO induction.

	Saline	Bevacizumab		Sildenafil
	Imm.	Imm.	6 h	Imm.
Total number of mice at study onset	58	32	35	27
Mortality
After surgery	15	5	14	1
After anesthesia	20	4	9	1
Total	35 (60%)	9 (28%)	23 (68%)	2 (0.74%)
Morbidity
After surgery	3 (13%)	0	0	6 (24%)
Survived procedure	20	23	12	19
Included in study	16	19	12	16
No stroke	4 (20%)	3 (13%)	0 (0%)	1 (6.3%)
Extreme damage	0	1 (4.3%)	0 (0%)	2 (10.5%)

Imm.: immediately injected after MCAO induction. 7 of 11 for histology (TTC) and immunohistochemistry and 5 for molecular analysis.