Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide

Figure 2

Effect on the rotarod test produced by the administration of different doses of HEPP, F-HEPP, Cl-HEPP, sodium valproate, and phenobarbital. . Black bar, selection test (180 s = 100%); grey bar, evaluation test (expressed as the median + standard error of the mean). The doses administered for each treatment were ED₅₀ against PTZ < ED₅₀ against MES < twice ED₅₀ against MES. ISS, isotonic saline solution (NaCl 0.09%); PEG-400 (30%), polyethyilenglicol-400 at 30% with ISS. Kruskal-Wallis post hoc Dunn’s, tatistically significant difference with respect to the selection test ().