Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide

Scheme 1

Chemical structure of compounds tested in this study. (a) 3(R)-3-Hydroxy-3-ethyl-3-phenylpropionamide, (R)-HEPP; (b) 3(R)-3-hydroxy, 3-ethyl, 3-(4′-chlorophenyl)propionamide, (R)-Cl-HEPP; (c) 3(R)-3-hydroxy, 3-ethyl, 3-(4′-fluorophenyl)propionamide, (R)-F-HEPP; (d) 3(S)-3-hydroxy-3-ethyl-3-phenylpropionamide, (S)-HEPP; (e) 3(S)-3-hydroxy, 3-ethyl, 3-(4′-chlorophenyl)propionamide, (S)-Cl-HEPP; (f) 3(S)-3-hydroxy, 3-ethyl, 3-(4′-fluorophenyl)propionamide, (S)-F-HEPP.