The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City
Table 4
Haplotype frequency and test statistics between bladder cancer patients and controls.
Numbers (frequency)
value
OR (95% CI)
Permutation test
Overall
Controls
Patients
[W, power]
G-T-T-G-T
34
25
9
0.251
0.614 (0.266–1.418)
0.317
G-T-T-A-C
33
27
6
0.350 (0.136–0.903)
[0.17, 61%]
G-C-C-G-T
22
15
7
0.747
0.854 (0.328–2.225)
0.814
G-T-T-A-T
17
7
10
3.000 (1.079–8.344)
[0.17, 61%]
G-C-C-A-C
12
5
7
0.077
2.826 (0.857–9.327)
0.112
A-C-T-G-T
8
8
0
0.056 [0.16, 56%]
A-T-T-G-T
13
5
8
3.292 (1.027–10.560)
0.065 [0.14, 45%]
G-T-C-G-T
7
4
3
0.651
1.421 (0.307–6.569)
0.696
G-C-C-A-T
3
3
0
0.201
0.549
G-T-T-G-C
6
3
3
0.429
1.912 (0.374–9.780)
0.430
G-C-T-G-T
6
4
2
0.935
0.931 (0.166–5.237)
1.000
A-T-T-A-C
4
4
0
0.139
0.308
G-C-T-A-C
3
0
3
[0.18, 66%]
A-C-C-G-C
2
2
0
0.298
0.542
A-C-T-A-C
1
0
1
0.171
0.347
A-C-C-A-C
1
0
1
0.171
0.350
Total value:
Global value of permutation : [0.46, 99%]
and . Haplotypes were constructed with CHRM3 SNPs: (from left to right) rs2165870, rs10802789, rs685550, rs7520974, and rs3738435. No OR was calculated for this haplotype. 10000 permutations were replicated to evaluate permutation value. The global value was calculated using a permutation test ( = 10,000).
