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BioMed Research International
Volume 2016, Article ID 4125731, 9 pages
Research Article

High Glucose-Induced PC12 Cell Death by Increasing Glutamate Production and Decreasing Methyl Group Metabolism

1School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
2Lishui Central Hospital, The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui 323000, China

Received 16 March 2016; Revised 18 May 2016; Accepted 23 May 2016

Academic Editor: Paula I. Moreira

Copyright © 2016 Minjiang Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In the Supplementary Material, typical 1H NMR spectra in extracellular extracts of the control and high glucose (HG) groups were illustrated in Figure S1. A clear separation was observed between the control and HG groups by multivariate analysis (PLS-DA) based on the extracellular metabolite profiles and the contributed metabolites were identified from its loading plot (Figure S2). In addition, Table S1 lists the changes in extracellular metabolite levels between the control and HG groups.

  1. Supplementary Material