Review Article
Treatment Strategies of Adult Primary Focal Segmental Glomerulosclerosis: A Systematic Review Focusing on the Last Two Decades
| | First author | Year | Design | Study | Country | PRED | TAC | CSA | MMF | AZA | No | CR | PR | NR | PR (BL) | PR (FU) | RL (%) | FU (m) |
| | Rydel [5] | 1995 | Retro | Cohort | USA | 1 | 0 | 0 | 0 | 0 | 30 | 12 | 3 | 15 | 13.6 ± 10 | | 67 | 62 | | Ponticelli [6] | 1999 | Retro | Cohort | Italy | 1 | 0 | 0 | 0 | 0 | 53 | 21 | 10 | 22 | | | 25.8 | | | Choi [7] | 2002 | Retro | Cohort | USA | 0 | 0 | 0 | 1 | 0 | 10 | 3 | 2 | 5 | 4.5 ± 3.1 | 2.6 ± 2.9 | | 7.9 | | Duncan [8] | 2004 | Pro | Cohort | UK | 0 | 1 | 0 | 0 | 0 | 6 | 0 | 6 | 0 | 11 ± 4.5 | 2.8 ± 2.5 | 0 | 12.8 | | Goumenos [9] | 2006 | Retro | Cohort | UK/Greece | 1 | 0 | 0 | 0 | 0 | 8 | | 5 | 3 | | | | | | Goumenos [9] | 2006 | Retro | Cohort | UK/Greece | 1 | 0 | 1 | 0 | 0 | 7 | | 6 | 1 | | | | | | Goumenos [9] | 2006 | Retro | Cohort | UK/Greece | 1 | 0 | 0 | 0 | 1 | 5 | | 4 | 1 | | | | | | Senthil Nayagam [10] | 2008 | Pro | RCT | India | 1 | 0 | 0 | 1 | 0 | 17 | 10 | 2 | 5 | | | 33.3 | 15.3 | | Senthil Nayagam [10] | 2008 | Pro | RCT | India | 1 | 0 | 0 | 0 | 0 | 16 | 9 | 2 | 5 | | | 27.3 | 16.2 | |
Jafry [11] | 2012 | Retro | Cohort | Egypt | 1 | 0 | 0 | 0 | 0 | 79 | 36 | 4 | 39 | 6 ± 4.4 | 4.6 ± 5.1 | 35 | 26 |
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AZA: azathioprine, CR: complete remission, CSA: cyclosporine A, FU: follow-up, MMF: mycophenolate mofetil, No: number, NR: no remission, PRED: prednisone/prednisolone, PR: partial remission, PR (BL): proteinuria baseline, PR (FU): proteinuria follow-up, Pro: prospective, Retro: retrospective, RL: relapse, and TAC: tacrolimus.
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