Treatment Strategies of Adult Primary Focal Segmental Glomerulosclerosis: A Systematic Review Focusing on the Last Two Decades

Table 2

First author	Year	Design	Study	Country	CSA	MMF	RTX	SIR	ACTH	No	CR	PR	NR	PR (BL)	PR (FU)	RL (%)	FU (m)
Lee [13]	1995	Pro	Observational	Korea	1	0	0	0	0	5	4	1	0				18
Cho [15]	2007	Pro	Clinical trial	USA	0	0	0	1	0	6	0	0	6	8.4 ± 6	12.3 ± 5.8		8
Dimkovic [14]	2009	Pro	Cohort	Serbia	0	1	0	0	0	10	3	5	2	5.1	1.9
Hogan [23]	2013	Pro	Observational	USA	0	0	0	0	1	6	0	2	4	7.7 ± 6.2	8 ± 9.7
Ruggenenti [16]	2014	Pro	Observational	Italy	0	0	1	0	0	8				0.3	0.2	37.5	12

ACTH: adrenocorticotropic hormone, CR: complete remission, CSA: cyclosporine A, FU: follow-up, MMF: mycophenolate mofetil, No: number, NR: no remission, PR: partial remission, PR (BL): proteinuria baseline, PR (FU): proteinuria follow-up, Pro: prospective, Retro: retrospective, RL: relapse, RTX: rituximab, and SIR: sirolimus.