Table 1: Clinical and pathological characteristics of 687 patients with UTUC stratified by tumor size.

  Tumor size
  ≤3 cm>3 cmChi-square or value
All385 (%)302 (%)

Age≤70221 (57.4)188 (62.3)1.6520.199
>70164 (42.6)114 (37.7)
Median (range)69 (20–90)68 (29–86)−1.4240.155
GenderMale155 (40.3)151 (50.0)6.5000.011
Female230 (59.7)151 (50.0)
Tobacco consumptionYes59 (15.3)65 (21.5)4.3960.036
No326 (84.7)237 (78.5)
Surgical approachOpen127 (33.0)93 (30.8)0.3740.541
Laparoscopic258 (67.0)209 (69.2)
Preoperative ureteroscopyYes61 (15.8)25 (8.3)8.8470.003
No324 (84.2)277 (91.7)
HydronephrosisPresence208 (54.0)126 (41.7)1.2410.265
Absence177 (46.0)176 (58.3)
T stagePTis-a-1165 (42.9)64 (21.2)59.636<0.001
PT2140 (36.4)102 (33.8)
PT377 (20.0)120 (39.7)
PT43 (0.8)16 (5.3)
GradeG116 (4.2)5 (1.7)11.6540.003
G2222 (57.7)146 (48.3)
G3147 (38.2)151 (50.0)
Lymph node statuscN0 or pN0363 (94.3)270 (89.4)5.5690.018
N+22 (5.7)32 (10.6)
Main tumor locationUreter197 (51.2)110 (36.4)14.886<0.001
Pelvis188 (48.8)192 (63.6)
Side of tumor locationRight189 (49.1)150 (49.7)0.0230.880
Left196 (50.9)152 (50.3)
Concomitant CISPresence10 (2.6)10 (3.3)0.3050.581
Absence375 (97.4)292 (96.7)
Tumor architecturePapillary302 (78.4)228 (75.5)0.8320.362
Sessile83 (21.6)74 (24.5)
MultifocalityYes97 (25.2)67 (22.2)0.8430.358
No288 (74.8)235 (77.8)
Tumor necrosisPresence32 (8.3)47 (15.6)8.7440.003
Absence353 (91.7)255 (84.4)
Squamous and/or glandular differentiationPresence38 (9.9)43 (14.2)3.1050.078
Absence347 (90.1)259 (85.8)

eGFR: estimated glomerular filtration rate; CIS: carcinoma in situ.
Statistically significant.