BioMed Research International / 2016 / Article / Tab 2

Research Article

The Influence of Tumor Size on Oncologic Outcomes for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy

Table 2

Univariate and multivariate analyses of predictive factors for worse cancer-specific survival.

Univariate analysis Multivariate analysis
HR95% CIHR95% CI

Age (>70 versus ≤70)1.4171.088–1.8460.0101.4551.107–1.9120.007
Gender (male versus female)1.6811.291–2.188<0.0011.6001.222–2.0960.001
Tobacco consumption (yes versus no)0.9820.697–1.3820.915
Surgical approach (open versus laparoscopic)1.0350.764–1.4040.823
Preoperative ureteroscopy (yes versus no)0.5170.323–0.8280.0060.6300.391–1.0140.057
Hydronephrosis (presence versus absence)1.4151.081–1.8540.0121.6751.262–2.224<0.001
T stage (pT3-4 versus pTis-a-1-2)2.5691.973–3.345<0.0012.2661.643–3.126<0.001
Tumor grade (G3 versus G1-2)1.5601.201–2.0280.0010.8240.583–1.1660.275
Lymph node status (Nx versus cN0 or pN0)2.6271.785–3.867<0.0011.8151.191–2.7670.006
Tumor size (>3 cm versus ≤3 cm)1.5071.159–1.9590.0021.1240.849–1.4890.414
Main tumor location (ureter versus pelvis)1.1390.876–1.4820.331
Concomitant CIS (presence versus absence)1.6730.912–3.0690.096
Tumor architecture (sessile versus papillary)1.9421.458–2.587<0.0011.1970.823–1.7420.347
Focality (multiple versus single)1.1490.858–1.5380.352
Tumor necrosis (presence versus absence)1.9131.336–2.739<0.0011.3570.913–2.0160.131
Squamous and/or glandular differentiation
(presence versus absence)
1.9571.346–2.846<0.0011.4030.927–1.8232.124

eGFR: estimated glomerular filtration rate; CIS: carcinoma in situ.
Statistically significant.

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