Table 3: Univariate and multivariate analyses of predictive factors for bladder recurrence survival.

Univariate analysisMultivariate analysis
HR95% CIHR95% CI

Age (≤70 versus >70)0.8990.687–1.1760.439
Gender (male versus female)1.1590.893–1.5040.268
Tobacco consumption (yes versus no)1.0300.737–1.4390.864
Surgical approach (open versus laparoscopic)1.0420.783–1.3870.776
Preoperative ureteroscopy (yes versus no)2.0851.527–2.847<0.0011.6561.196–2.2910.002
Hydronephrosis (presence versus absence)1.2530.962–1.6320.095
T stage (pTis-a-1-2 versus pT3-4)1.4621.071–1.9960.0171.0340.730–1.4640.850
Tumor grade (G1-2 versus G3)1.5871.201–2.0920.0011.3911.028–1.8800.032
Lymph node status (cN0 or pN0 versus Nx)4.5251.684–12.1950.0033.2791.202–8.9290.020
Tumor size (≤3 cm versus >3 cm)1.4221.082–1.8690.0121.1960.898–1.5950.219
Main tumor location (ureter versus pelvis)1.3961.076–1.8110.0121.2530.955–1.6460.104
Concomitant CIS (presence versus absence)1.1550.571–2.3400.688
Tumor architecture (papillary versus sessile)0.7390.521–1.0470.089
Focality (multiple versus single)1.8131.381–2.381<0.0011.6011.213–2.1140.001
Tumor necrosis (presence versus absence)0.8260.527–1.2940.404
Squamous and or glandular differentiation (presence versus absence)0.6820.416–1.1190.130

eGFR: estimated glomerular filtration rate; CIS: carcinoma in situ.
Statistically significant.