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BioMed Research International
Volume 2016, Article ID 4380845, 5 pages
http://dx.doi.org/10.1155/2016/4380845
Research Article

Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity

1Lluita Contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Internal Medicine Service, Autonomous University of Barcelona, Barcelona, Spain
2Statistics and Operations Research, Technical University of Catalunya, Barcelona, Spain
3IrsiCaixa Foundation, Barcelona, Spain
4Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Barcelona, Spain

Received 22 September 2016; Revised 8 November 2016; Accepted 23 November 2016

Academic Editor: Lucia Lopalco

Copyright © 2016 Anna Bonjoch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce. Methods. This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity. We assessed the evolution of renal parameters after discontinuation of this drug. Results. We included 59 patients, who were followed up for 72 weeks. Most were male (41, 69.5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55.4 (28; 87.7) months. Most patients were receiving PI-based treatments (67%). At the final visit, most of the subjects showed complete recovery (35, 59.3%) or improvement (13 subjects, 22%). Significant improvements were observed in creatinine levels (from 84.9 [73.8; 97.5] to 78 [69.6; 91] μmol/L, ), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87.7 [67; 99] to 89.9 [73.6; 99.3] mL/min/1.73 m2, ), and number of patients with eGFR <60 mL/min/1.73 m2 (from 9 [15.3%] to 1 [1.7%], ). A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13.6%], ). Conclusions. Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity.