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BioMed Research International
Volume 2016, Article ID 4567580, 12 pages
http://dx.doi.org/10.1155/2016/4567580
Research Article

Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cells In Vitro and In Vivo

1Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China
2Department of Oncology, Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China
3Department of Respiratory, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
4Department of Traditional Chinese Medicine, Wujing Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200241, China
5Department of Rehabilitation, The Second People Huaian Hospital, Xuzhou Medical College, Huaian 223002, China
6Department of Oncology, Huadong Hospital, Fudan University, Shanghai 200040, China
7Department of Pharmacy, Huadong Hospital, Fudan University, Shanghai 200040, China

Received 5 May 2016; Accepted 20 July 2016

Academic Editor: Pratheeshkumar Poyil

Copyright © 2016 XinGang Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-B. Liao, Y.-Z. Liang, Y.-L. Chen et al., “Novel patchouli alcohol ternary solid dispersion pellets prepared by poloxamers,” Iranian Journal of Pharmaceutical Research, vol. 14, no. 1, pp. 15–26, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. W. Jia, C. Wang, Y. Wang et al., “Qualitative and quantitative analysis of the major constituents in Chinese medical preparation Lianhua-Qingwen capsule by UPLC-DAD-QTOF-MS,” The Scientific World Journal, vol. 2015, Article ID 731765, 19 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. L. F. Hu, S. P. Li, H. Cao et al., “GC-MS fingerprint of Pogostemon cablin in China,” Journal of Pharmaceutical and Biomedical Analysis, vol. 42, no. 2, pp. 200–206, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. K. Swamy and U. R. Sinniah, “A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.: an aromatic medicinal plant of industrial importance,” Molecules, vol. 20, no. 5, pp. 8521–8547, 2015. View at Publisher · View at Google Scholar
  5. S. P. Bhatia, C. S. Letizia, and A. M. Api, “Fragrance material review on patchouli alcohol,” Food and Chemical Toxicology, vol. 46, supplement 11, pp. S255–S256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. Zhao, J. Lu, K. Leung, C. L. Chan, and Z.-H. Jiang, “Determination of patchoulic alcohol in Herba Pogostemonis by GC-MS-MS,” Chemical & Pharmaceutical Bulletin, vol. 53, no. 7, pp. 856–860, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. Y.-F. Xian, Y.-C. Li, S.-P. Ip, Z.-X. Lin, X.-P. Lai, and Z.-R. Su, “Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages,” Experimental and Therapeutic Medicine, vol. 2, no. 3, pp. 545–550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. B. Jeong, Y. K. Shin, and S.-H. Lee, “Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells,” Food and Chemical Toxicology, vol. 55, pp. 229–233, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Kiyohara, C. Ichino, Y. Kawamura, T. Nagai, N. Sato, and H. Yamada, “Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth.,” Journal of Natural Medicines, vol. 66, no. 1, pp. 55–61, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Wu, B. Li, X. Wang, M. Jin, and G. Wang, “Inhibitory effect and possible mechanism of action of patchouli alcohol against influenza A (H2N2) virus,” Molecules, vol. 16, no. 8, pp. 6489–6501, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Y.-C. Li, S.-Z. Peng, H.-M. Chen et al., “Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice,” International Immunopharmacology, vol. 12, no. 1, pp. 294–301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. X.-L. Wu, D.-H. Ju, J. Chen et al., “Immunologic mechanism of patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro,” Current Microbiology, vol. 67, no. 4, pp. 431–436, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Yang, X. Zhang, S.-P. Yang, and X.-D. Yu, “Preliminary antibacterial evaluation of the chemical compositions in Herba pogostemonis oil,” Pakistan Journal of Pharmaceutical Sciences, vol. 26, no. 6, pp. 1173–1179, 2013. View at Google Scholar · View at Scopus
  14. X.-D. Yu, J.-H. Xie, Y.-H. Wang et al., “Selective antibacterial activity of patchouli alcohol against Helicobacter pylori based on inhibition of urease,” Phytotherapy Research, vol. 29, no. 1, pp. 67–72, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Pattnaik, V. R. Subramanyam, and C. Kole, “Antibacterial and antifungal activity of ten essential oils in vitro,” Microbios, vol. 86, no. 349, pp. 237–246, 1996. View at Google Scholar · View at Scopus
  16. X. Yang, X. Zhang, S.-P. Yang, and W.-Q. Liu, “Evaluation of the antibacterial activity of patchouli oil,” Iranian Journal of Pharmaceutical Research, vol. 12, no. 3, pp. 307–316, 2013. View at Google Scholar · View at Scopus
  17. D. Vázquez-Sánchez, M. L. Cabo, and J. J. Rodríguez-Herrera, “Antimicrobial activity of essential oils against Staphylococcus aureus biofilms,” Food Science and Technology International, vol. 21, no. 8, pp. 559–570, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Pavela, “Insecticidal properties of several essential oils on the house fly (Musca domestica L.),” Phytotherapy Research, vol. 22, no. 2, pp. 274–278, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Tan, J. Su, D. Wu et al., “Kinetics and mechanism study of competitive inhibition of Jack-Bean urease by baicalin,” The Scientific World Journal, vol. 2013, Article ID 879501, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. Y.-C. Xie and F. Tang, “Protective effect of Pogostemon cablin on membrane fluidity of intestinal epithelia cell in ischemia/ reperfusion rats after ischemia/reperfusion,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 29, no. 7, pp. 639–641, 2009. View at Google Scholar · View at Scopus
  21. J.-L. Yu, X.-S. Zhang, X. Xue, and R.-M. Wang, “Patchouli alcohol protects against lipopolysaccharide-induced acute lung injury in mice,” The Journal of Surgical Research, vol. 194, no. 2, pp. 537–543, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. H. W. Kim, S. J. Cho, B.-Y. Kim, S. I. Cho, and Y. K. Kim, “Pogostemon cablin as ROS scavenger in oxidant-induced cell death of human neuroglioma cells,” Evidence-Based Complementary and Alternative Medicine, vol. 7, no. 2, pp. 239–247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Y.-C. Tsai, H.-C. Hsu, W.-C. Yang, W.-J. Tsai, C.-C. Chen, and T. Watanabe, “α-Bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin,” Fitoterapia, vol. 78, no. 1, pp. 7–11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Yang, K. Kinoshita, K. Koyama et al., “Anti-emetic principles of Pogostemon cablin (Blanco) Benth,” Phytomedicine, vol. 6, no. 2, pp. 89–93, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. B. Jeong, J. Choi, Z. Lou, X. Jiang, and S.-H. Lee, “Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells,” International Immunopharmacology, vol. 16, no. 2, pp. 184–190, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Yu, Y. Qi, G. Luo, H.-Q. Duan, and J. Zhou, “Extraction and analysis of the essential oil in Pogostemon cablin by enzymatic hydrolysis and inhibitory activity against Hela cell proliferation,” Zhong Yao Cai, vol. 35, no. 5, pp. 796–799, 2012. View at Google Scholar · View at Scopus
  27. D. J. Giard, S. A. Aaronson, G. J. Todaro et al., “In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors,” Journal of the National Cancer Institute, vol. 51, no. 5, pp. 1417–1423, 1973. View at Google Scholar · View at Scopus
  28. A. Spira, B. Halmos, and C. A. Powell, “Update in lung cancer 2014,” American Journal of Respiratory and Critical Care Medicine, vol. 192, no. 3, pp. 283–294, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. G. P. Kalemkerian, “Advances in pharmacotherapy of small cell lung cancer,” Expert Opinion on Pharmacotherapy, vol. 15, no. 16, pp. 2385–2396, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Sundar, R. Soong, B.-C. Cho, J. R. Brahmer, and R. A. Soo, “Immunotherapy in the treatment of non-small cell lung cancer,” Lung Cancer, vol. 85, no. 2, pp. 101–109, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Shi, B. Tan, G. Ji et al., “Zedoary oil (Ezhu You) inhibits proliferation of AGS cells,” Chinese Medicine, vol. 8, no. 1, article 13, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Li, D. Nijhawan, I. Budihardjo et al., “Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade,” Cell, vol. 91, no. 4, pp. 479–489, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Ondroušková and B. Vojtěšek, “Programmed cell death in cancer cells,” Klinická Onkologie, vol. 27, supplement 1, pp. S7–S14, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Thomas, B. A. Quinn, S. K. Das et al., “Targeting the Bcl-2 family for cancer therapy,” Expert Opinion on Therapeutic Targets, vol. 17, no. 1, pp. 61–75, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Shamas-Din, J. Kale, B. Leber, and D. W. Andrews, “Mechanisms of action of Bcl-2 family proteins,” Cold Spring Harbor Perspectives in Biology, vol. 5, no. 4, Article ID a008714, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Degli Esposti and C. Dive, “Mitochondrial membrane permeabilisation by Bax/Bak,” Biochemical and Biophysical Research Communications, vol. 304, no. 3, pp. 455–461, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Estaquier, F. Vallette, J.-L. Vayssiere, and B. Mignotte, “The mitochondrial pathways of apoptosis,” in Advances in Mitochondrial Medicine, R. Scatena, P. Bottoni, and B. Giardina, Eds., vol. 942 of Advances in Experimental Medicine and Biology, pp. 157–183, 2012. View at Publisher · View at Google Scholar
  38. J. D. Ly, D. R. Grubb, and A. Lawen, “The mitochondrial membrane potential Ψm in apoptosis; an update,” Apoptosis, vol. 8, no. 2, pp. 115–128, 2003. View at Publisher · View at Google Scholar
  39. M. P. Cunningham, S. Essapen, H. Thomas et al., “Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer,” International Journal of Oncology, vol. 27, no. 2, pp. 317–325, 2005. View at Google Scholar · View at Scopus
  40. M. Shimizu, A. Deguchi, J. T. E. Lim, H. Moriwaki, L. Kopelovich, and I. B. Weinstein, “(−)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells,” Clinical Cancer Research, vol. 11, no. 7, pp. 2735–2746, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. P. K. Kandala, S. E. Wright, and S. K. Srivastava, “Blocking epidermal growth factor receptor activation by 3,3′-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo,” The Journal of Pharmacology and Experimental Therapeutics, vol. 341, no. 1, pp. 24–32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. M. R. Maiello, A. D'Alessio, S. Bevilacqua, M. Gallo, N. Normanno, and A. De Luca, “EGFR and MEK blockade in triple negative breast cancer cells,” Journal of Cellular Biochemistry, vol. 116, no. 12, pp. 2778–2785, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. S. M. Gadgeel, S. Ali, P. A. Philip, F. Ahmed, A. Wozniak, and F. H. Sarkar, “Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor,” Cancer, vol. 110, no. 12, pp. 2775–2784, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Li, Y. Gao, L. Zhang, J. Zeng, D. He, and Y. Sun, “Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma,” Cancer Letters, vol. 272, no. 1, pp. 61–69, 2008. View at Publisher · View at Google Scholar · View at Scopus