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BioMed Research International
Volume 2016, Article ID 4648287, 11 pages
http://dx.doi.org/10.1155/2016/4648287
Research Article

Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing

1Department of Materials Engineering, Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentų 56, LT-51424 Kaunas, Lithuania
2Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, LT-50161 Kaunas, Lithuania
3Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Eivenių g. 4, LT-50161 Kaunas, Lithuania

Received 25 September 2015; Revised 15 January 2016; Accepted 18 January 2016

Academic Editor: Ming-Fa Hsieh

Copyright © 2016 Erika Adomavičiūtė et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity on Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Bacillus cereus, and Candida albicans strains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.