Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate

Table 1

Protection level induced in BALB/c mice following immunization with rSjLGL and infection with 40 cercariae.

	Adult worms; mean ± SD; (% reduction)	Liver eggs; mean ± SD; (% reduction)	Egg hatching rate (% reduction)
Test 1
PBS+ISA206	12 ± 5.78	15446.27 ± 4518.95	6.43 ± 2.44
rSjLGL+ISA206	12.6 ± 6.22	17286.02 ± 5933.09	1.55 ± 0.79
	(−7.57)	(−11.91)	(75.84)
Test 2
PBS+ISA206	14.5 ± 5.19	60374.84 ± 26931.24	2.42 ± 0.96
rSjLGL+ISA206	18.2 ± 2.94	64699.45 ± 32697.79	1.09 ± 0.29
	(−25.51)	(−7.16)	(54.62)
Test 3
PBS+ISA206	13.9 ± 5.68	35537.82 ± 17296.66	4.20 ± 2.13
rSjLGL+ISA206	12.66 ± 5.14	17820.01 ± 8997.366	1.96 ± 0.90
	(8.87)	(49.86)	(53.24)
Test 4
PBS+ISA206	22 ± 8.07	30513.28 ± 13690.01	4.15 ± 2.6
rSjLGL+ISA206	11 ± 2.7	25081.94 ± 15991.31	1.59 ± 1.01
	(50.0)	(33.47)	(61.71)
Test 5
PBS+ISA206	17.14 ± 3.76	50135.58 ± 7204.55	7.57 ± 3.43
rSjLGL+ISA206	14.92 ± 6.19	35478.2 ± 9444.48	3.44 ± 1.19
	(12.91)	(29.23)	(54.49)

Tests 1–5, . Statistically significant compared with the control group (), ().