|
| Study (yr) | Intervention treatment | Study type | Number of subjects | Subject characteristic [age (yr); gender] | Previous therapy | Concurrent treatment | Follow-up (mo) | Outcome measures | Results | Authors’ conclusion |
|
| Pak (2011) [20] | Adipose SVF (ADSC) + PRP via percutaneous injections | Case report | 2 | 70 and 79; 2 F with chronic knee pain | Various treatments without any success | None | 3 | VAS; functions (FRI, ROM); MRI | VAS/function improvements and MRI evidence of cartilage regeneration | ADSC + PRP: potentially effective in regenerating cartilage in humans |
|
| Koh and Choi (2012) [52] | Adipose SVF (ADSC) + PRP via percutaneous injections | Nonrandomized, retrospective, comparative study: ADSC + PRP versus PRP alone | 25
Study group (ADSC + PRP): 25; control group (PRP alone): 25 | Study group: mean 54.1 (range, 34–69); 8 M and 17 F | Various treatments without any success | None | 16.4 | VAS; functions (Lysholm, Tegner) | ADSC + PRP: more effective than PRP-control group | ADSC + PRP: potentially effective in patients with cartilage defects |
|
| Pak et al. (2013) [44] | Adipose SVF (ADSC) + PRP via percutaneous injections | Retrospective cohort study | 91 | Mean 51.23 ± 1.50 (range, 18–78); 45 M and 46 F | Various treatments without any success | None | 26.62 ± 0.32 | VAS; functions | Statistically significant improvement in both VAS and functions | ADSC + PRP: safe and potentially effective |
|
| Pak et al. (2013) [47] | Adipose SVF (ADSC) + PRP via percutaneous injections | Case series | 3 | 43 and 63; 2 F
54; 1 M
All with chronic knee pain | Various treatments without any success | None | 3 | VAS; functions (FRI, ROM); MRI | VAS/function improvements and MRI evidence of cartilage regeneration | ADSC + PRP: effective in treating chondromalacia patellae patients |
|
| Koh et al. (2013) [53] | Adipose SVF (ADSC) + PRP via percutaneous injection | Case series | 18 | Mean 54.6; 6 M and 12 F | Various treatments without any success | Arthroscopic lavage before knee-fat-pad-derived adipose SVF + PRP injection | 24.3 | VAS; functions (WOMAC, Lysholm); MRI | VAS/function/MRI improvements | ADSC + PRP: effective in treating OA of knees |
|
| Koh et al. (2015) [22] | Adipose SVF (ADSC) + PRP under arthroscopic guidance | Case series | 30 for adipose SVF + PRP injection; 16 for second-look arthroscopy | Mean 70.3 (range, 65–80); 5 M and 25 F | Various treatments without any success | Arthroscopic lavage before ADSCs + PRP injection | 24 | VAS; functions; 2nd-look arthroscopy | VAS/function improvements; improved and maintained cartilage status | ADSCs + PRP: effective in treating elderly patients with OA |
|
| Pak et al. (2014) [48] | Adipose SVF (ADSC) + PRP via percutaneous injections | Case report | 1 | 32; 1 F with chronic knee pain due to meniscus tear | Various treatments without any success | None | 3 | VAS; functions (FRI, ROM); MRI | VAS/function improvements and MRI evidence of cartilage regeneration | ADSC + PRP: effective in treating cartilage defect lesions, including meniscus tear |
|
| Bui et al. (2014) [54] | Adipose SVF (ADSC) + PRP via percutaneous injections | Case series | 21 | >18; ND | Various treatments without any success | None | 8.5 | VAS; functions; MRI | VAS/function/MRI improvements | ADSC + PRP: effective in treating OA of knees |
|
| Jo et al. (2014) [21] | Culture-expanded ADSC via arthroscopic injections | Randomized double-blind dose escalation study (a proof-of-concept clinical trial) | 18 | 61–65; 3 M and 15 F | Various treatments without any success | None | 6 | VAS; functions; MRI; arthroscopy; histology | VAS/function/MRI/
arthroscopic/histological
improvements | 1.0 × 108
ADSCs into the osteoarthritic knee improved function and pain of the knee joint. Radiological,
arthroscopic, and histological measures
demonstrated
regeneration of
hyaline-like articular cartilage |
|
| Koh et al. (2014) [23] | Adipose SVF (ADSC) + PRP under arthroscopic guidance | Case series | 35 with 37 knee joints | Mean 57.4 (range, 48–69); 14 M and 21 F | Various treatments without any success | Arthroscopic lavage before adipose SVF + PRP injection | 12.7 | VAS; functions; arthroscopy | 94% patients had excellent clinical improvement; 76% had abnormal repair tissue | Scaffolds may be needed to treat patients with large cartilage lesions |
|
| Koh et al. (2014) [55] | Adipose SVF (ADSC) + PRP under arthroscopic guidance | Comparative study: adipose SVF + PRP versus PRP only | 44 | ND | Various treatments without any success | Open-wedge high tibial osteotomy | 24 | VAS; functions; arthroscopy | Adipose SVF + PRP is more effective than PRP alone | ADSC therapy, in conjunction with HTO, mildly improved cartilage healing and showed good clinical results compared with PRP only |
|
| Kim et al. (2015) [49] | Adipose SVF (ADSC) under arthroscopic guidance | Comparative study:
adipose SVF versus adipose SVF + fibrin glue (as a scaffold) | 54 | Mean 57.5 ± 5.8; 22 M and 32 F | Various treatments without any success | None | 28.6 | VAS; functions; arthroscopy | No significant difference | Clinical and arthroscopic outcomes of ADSC implantation were encouraging for OA knees in both groups, although there were no significant differences in outcome scores between groups |
|
| Michalek et al. (2015) [56] | Adipose SVF (ADSC) via percutaneous injection | Multicenter case control study | 1,114 | Median 62 (range, 19–94); 589 M and 525 F | Various treatments without any success | None | Median 17.2 | VAS; functions | VAS/function improvements | Adipose SVF is a novel and promising treatment approach for patients with degenerative OA. ADSC is safe and cost-effective |
|
