A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation

Table 4

HR-QOL amelioration at the different times of treatment (, , , and , days) and at the follow-up period, that is, 30 days after the last product intake (90, days) between F_1 and F_2 groups compared with F_3. Bloating, abdominal pain, constipation, abdominal cramps, and flatulence were assessed on a numbering scale from 0 to 10 for each item subjects scored. Data are mean ± SE. In brackets is reported the intergroups (versus placebo) statistical analysis.

Time (days)	F_1	P value	F_2	P value	F_3	P value	F_1 vs F_3 (P value)	F_2 vs F_3 (P value)
0	31.2 ± 1.0		32.0 ± 0.9		30.0 ± 0.9
10	28.3 ± 0.9	<0.01	27.0 ± 0.8	<0.001	28.9 ± 1.0	>0.05	>0.05	>0.05
30	23.1 ± 0.9	<0.001	22.8 ± 0.8	<0.001	27.8 ± 1.1	<0.05	<0.01	<0.001
60	20.2 ± 0.9	<0.001	20.4 ± 0.9	<0.001	26.9 ± 1.2	<0.001	<0.001	<0.001
90	22.2 ± 1.0	<0.001	22.0 ± 0.8	<0.05	28.7 ± 1.2	<0.01	<0.001	<0.001