BioMed Research International / 2016 / Article / Tab 4

Clinical Study

A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation

Table 4

HR-QOL amelioration at the different times of treatment (, , , and , days) and at the follow-up period, that is, 30 days after the last product intake (90, days) between F_1 and F_2 groups compared with F_3. Bloating, abdominal pain, constipation, abdominal cramps, and flatulence were assessed on a numbering scale from 0 to 10 for each item subjects scored. Data are mean ± SE. In brackets is reported the intergroups (versus placebo) statistical analysis.

Time (days)F_1P valueF_2P valueF_3P valueF_1 vs F_3 (P value)F_2 vs F_3 (P value)

031.2 ± 1.032.0 ± 0.930.0 ± 0.9
1028.3 ± 0.9<0.0127.0 ± 0.8<0.00128.9 ± 1.0>0.05>0.05>0.05
3023.1 ± 0.9<0.00122.8 ± 0.8<0.00127.8 ± 1.1<0.05<0.01<0.001
6020.2 ± 0.9<0.00120.4 ± 0.9<0.00126.9 ± 1.2<0.001<0.001<0.001
9022.2 ± 1.0<0.00122.0 ± 0.8<0.0528.7 ± 1.2<0.01<0.001<0.001

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