Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016 (2016), Article ID 4753170, 8 pages
http://dx.doi.org/10.1155/2016/4753170
Research Article

Atypical Complete Femoral Fractures Associated with Bisphosphonate Use or Not Associated with Bisphosphonate Use: Is There a Difference?

1Department of Orthopaedic Surgery, Seoul Medical Center, Seoul, Republic of Korea
2Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
3Department of Orthopaedic Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea

Received 25 August 2016; Accepted 23 October 2016

Academic Editor: Sheldon Lin

Copyright © 2016 Sang-Min Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. A. Einhorn, “The cell and molecular biology of fracture healing,” Clinical Orthopaedics and Related Research, no. 355, supplement, pp. S7–S21, 1998. View at Google Scholar · View at Scopus
  2. T. Mashiba, S. Mori, S. Komatsubara et al., “THe effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib,” Journal of Bone and Mineral Metabolism, vol. 23, no. 1, pp. 36–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. C. V. Odvina, J. E. Zerwekh, D. S. Rao, N. Maalouf, F. A. Gottschalk, and C. Y. C. Pak, “Severely suppressed bone turnover: a potential complication of alendronate therapy,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 3, pp. 1294–1301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Abrahamsen, “Bisphosphonate adverse effects, lessons from large databases,” Current Opinion in Rheumatology, vol. 22, no. 4, pp. 404–409, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. Kang, Y. Y. Won, J. O. Kim et al., “Atypical femoral fractures after anti-osteoporotic medication: A Korean Multicenter Study,” International Orthopaedics, vol. 38, no. 6, pp. 1247–1253, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. A. S. Neviaser, J. M. Lane, B. A. Lenart, F. Edobor-Osula, and D. G. Lorich, “Low-energy femoral shaft fractures associated with alendronate use,” Journal of Orthopaedic Trauma, vol. 22, no. 5, pp. 346–350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. W. Nieves and F. Cosman, “Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates,” Current Osteoporosis Reports, vol. 8, no. 1, pp. 34–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Saita, M. Ishijima, A. Mogami et al., “The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment,” Bone, vol. 66, pp. 105–110, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. N. B. Watts and D. L. Diab, “Long-term use of bisphosphonates in osteoporosis,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 4, pp. 1555–1565, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. D. M. Black, M. P. Kelly, H. K. Genant et al., “Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur,” The New England Journal of Medicine, vol. 362, no. 19, pp. 1761–1771, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. M. Dell, A. L. Adams, D. F. Greene et al., “Incidence of atypical nontraumatic diaphyseal fractures of the femur,” Journal of Bone and Mineral Research, vol. 27, no. 12, pp. 2544–2550, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. A. C. Feldstein, D. Black, N. Perrin et al., “Incidence and demography of femur fractures with and without atypical features,” Journal of Bone and Mineral Research, vol. 27, no. 5, pp. 977–986, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Schilcher, K. Michaëlsson, and P. Aspenberg, “Bisphosphonate use and atypical fractures of the femoral shaft,” The New England Journal of Medicine, vol. 364, no. 18, pp. 1728–1737, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Shane, D. Burr, P. R. Ebeling et al., “Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the american society for bone and mineral Research,” Journal of Bone and Mineral Research, vol. 25, no. 11, pp. 2267–2294, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Shane, D. Burr, B. Abrahamsen et al., “Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research,” Journal of Bone and Mineral Research, vol. 29, no. 1, pp. 1–23, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Oh, Y. Wakabayashi, Y. Kurosa, M. Ishizuki, and A. Okawa, “Stress fracture of the bowed femoral shaft is another cause of atypical femoral fracture in elderly Japanese: a case series,” Journal of Orthopaedic Science, vol. 19, no. 4, pp. 579–586, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. S. S. Chan, Z. S. Rosenberg, K. Chan, and C. Capeci, “Subtrochanteric femoral fractures in patients receiving long-term alendronate therapy: imaging features,” American Journal of Roentgenology, vol. 194, no. 6, pp. 1581–1586, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. K. A. Egol, J. H. Park, Z. S. Rosenberg, V. Peck, and N. C. Tejwani, “Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails,” Clinical Orthopaedics and Related Research, vol. 472, no. 9, pp. 2728–2734, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. M. K. Grady, J. T. Watson, and L. K. Cannada, “Treatment of femoral fracture nonunion after long-term bisphosphonate use,” Orthopedics, vol. 35, no. 6, pp. e991–e995, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. M. L. Prasarn, J. Ahn, D. L. Helfet, J. M. Lane, and D. G. Lorich, “Bisphosphonate-associated femur fractures have high complication rates with operative fixation,” Clinical Orthopaedics and Related Research, vol. 470, no. 8, pp. 2295–2301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. A. Weil, G. Rivkin, O. Safran, M. Liebergall, and A. J. Foldes, “The outcome of surgically treated femur fractures associated with long-term bisphosphonate use,” Journal of Trauma, vol. 71, no. 1, pp. 186–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Sasaki, N. Miyakoshi, M. Hongo, Y. Kasukawa, and Y. Shimada, “Low-energy diaphyseal femoral fractures associated with bisphosphonate use and severe curved femur: a case series,” Journal of Bone and Mineral Metabolism, vol. 30, no. 5, pp. 561–567, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. K. J. Koval, G. B. Aharonoff, A. D. Rosenberg, R. L. Bernstein, and J. D. Zuckerman, “Functional outcome after hip fracture: effect of general versus regional anesthesia,” Clinical Orthopaedics and Related Research, no. 348, pp. 37–41, 1998. View at Google Scholar · View at Scopus
  24. R. M. Kay, K. A. Jaki, and D. L. Skaggs, “The effect of femoral rotation on the projected femoral neck-shaft angle,” Journal of Pediatric Orthopaedics, vol. 20, no. 6, pp. 736–739, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. D. B. Whelan, M. Bhandari, M. D. McKee et al., “Interobserver and intraobserver variation in the assessment of the healing of tibial fractures after intramedullary fixation,” The Journal of Bone & Joint Surgery—British Volume, vol. 84, no. 1, pp. 15–18, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Marsh, “Concepts of fracture union, delayed union, and nonunion,” Clinical Orthopaedics and Related Research, no. 355, supplement, pp. S22–S30, 1998. View at Google Scholar · View at Scopus
  27. S. C. Tan, S. B. J. Koh, S. K. Goh, and T. S. Howe, “Atypical femoral stress fractures in bisphosphonate-free patients,” Osteoporosis International, vol. 22, no. 7, pp. 2211–2212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Giusti, N. A. T. Hamdy, O. M. Dekkers, S. R. Ramautar, S. Dijkstra, and S. E. Papapoulos, “Atypical fractures and bisphosphonate therapy: a cohort study of patients with femoral fracture with radiographic adjudication of fracture site and features,” Bone, vol. 48, no. 5, pp. 966–971, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. S. M. Kim, W. Rhee, S. Ha, J. H. Lim, and I. T. Jang, “Influence of alendronate and endplate degeneration to single level posterior lumbar spinal interbody fusion,” Korean Journal of Spine, vol. 11, no. 4, pp. 221–226, 2014. View at Publisher · View at Google Scholar
  30. S. Ohtori, G. Inoue, S. Orita et al., “Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective,” Spine, vol. 38, no. 8, pp. E487–E492, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Donnelly, A. Saleh, A. Unnanuntana, and J. M. Lane, “Atypical femoral fractures: epidemiology, etiology, and patient management,” Current Opinion in Supportive and Palliative Care, vol. 6, no. 3, pp. 348–354, 2012. View at Publisher · View at Google Scholar · View at Scopus