Unilateral Opening of Rat Blood-Brain Barrier Assisted by Diagnostic Ultrasound Targeted Microbubbles Destruction

Figure 1

Diagrams of transtemporal exposure with DUS and brain perfusion image with microbubbles in rats. (a) The long axis of the M4S probe was kept consistent with the connection line of the right eye and ear of rat, and a tilting position was fixed with an angle of to the horizontal plane during the exposure. (b) Brain parenchyma was mildly enhanced after microbubbles infusion in rats (white box indicates the perfusion of the targeted area and white arrowheads indicate the skull of the contralateral side of rat).

(a)

(b)