Unilateral Opening of Rat Blood-Brain Barrier Assisted by Diagnostic Ultrasound Targeted Microbubbles Destruction

Figure 2

EB extravasation of brain parenchyma. (a) A substantial EB extravasation was observed at the coronal slices (front and reverse sides) of the DUS-exposed hemisphere while it is not visible at the contralateral side. (b) Histogram of the quantification analysis of the EB extravasation grading: a significantly higher grade was indicated in the DUS-exposed hemisphere than the contralateral hemisphere (). (c) Histogram of the quantification analysis of the EB extraction from the brain: a significantly higher value was shown in the DUS-exposed side compared to the contralateral side ().

(a)

(b)

(c)