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BioMed Research International
Volume 2016, Article ID 4863609, 8 pages
Review Article

Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features

1Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
2Department of Gastroenterological Surgery, Hangzhou First People’s Hospital, School of Clinical Medicine, Nanjing Medical University, Hangzhou 310006, China

Received 23 June 2016; Accepted 17 August 2016

Academic Editor: Xin-yuan Guan

Copyright © 2016 Yang Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Long noncoding RNA (lncRNA) H19 has been reported to be upregulated in malignant digestive tumors, but its clinical relevance is not yet established. The meta-analysis was to investigate the association between H19 expression and pathological features of digestive system cancers. The databases of PubMed, EMBase, Web of Science, CNKI, and WanFang were searched for the related studies. A total of 478 patients from 6 studies were finally included. The meta-analysis showed that the patient group of high H19 expression had a higher risk of poorly differentiated grade, deep tumor invasion (T2 stage or more), lymph node metastasis, and advanced TNM stage than the group of low H19 expression, although there was no difference between them in terms of distant metastasis. Therefore, the high expression of lncRNA H19 might predict poor oncological outcomes of patients with digestive system cancers.