Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma

Figure 4

D. cinnabari induces apoptosis through intrinsic caspase pathway. Luminescence intensity of caspases 3/7, 8, and 9 in H400 cells treated with DC extract, fractions DCc and DCd, and subfractions DCc15 and DCd16 of D. cinnabari at concentration of IC₅₀ for 24 hours. Untreated cells were used as negative control. Data was expressed as mean ± SEM (). Significant difference as compared to negative control () when statistical analysis was performed.