Research Article
Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma
Table 3
Cytotoxicity (IC50) against NHOF cells and selectivity index (SI) of selected active extract, fractions, and subfractions of D. cinnabari.
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Data are presented as mean ± SEM in triplicate. Selectivity index is defined as the ratio of cytotoxicity (IC50 values) on normal human oral fibroblast (NHOF) cells to cancer cells (SI = IC50 NHOF cells/IC50 on H400 cells). SI values greater than 3 are considered to have high selectivity towards cancer cells. ND: not detected (as the IC50 values on NHOF >30 μg/mL). DC extract: methanol extract of D. cinnabari. DCc and DCd: fractions of D. cinnabari. DCc15: subfraction isolated from fraction DCc. DCd16: subfraction isolated from fraction DCd. |