β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

Table 3

Association between the expression of WIF1 and β-catenin and clinicopathological parameters of CC (stages IA–IIB).

Variable	Cases		WIF1			β-Catenin
	Number	(%)	Negative	Positive		Negative	Positive
Histologic subtype
Squamous cell carcinoma	172	87.8	133	39	NS	58	114	NS
Adenocarcinoma	24	12.2	16	8		5	19
FIGO stage
IA	16	8.2	13	3	NS	6	10	NS
IB1, IIA1	102	52.0	77	25		31	71
IB2, IIA2	64	32.7	46	18		25	39
IIB	14	7.1	13	1		1	13
Tumor grade
G1	35	19.2	27	8	NS	6	29	NS
G2/G3	147	80.8	112	35		41	106
Parametrial invasion
Negative	186	94.9	141	45	NS	62	124	NS
Positive	10	5.1	8	2		1	9
Surgical margin involved
No	189	96.4	143	46	NS	63	126	NS
Yes	7	3.6	6	1		0	7
Lymph node metastasis
Negative	142	72.4	103	39	NS	51	91	NS
Positive	54	27.6	46	8		12	42
Tumor size (cm)
≤4	117	59.7	90	27	NS	36	81	NS
>4	79	40.3	59	20		27	52
Cervical stromal invasion
≤ one second	86	43.9	56	30	0.002	27	59	NS
> one second	110	56.1	93	17		34	76
Lymphovascular invasion
Negative	93	61.6	64	29	0.035	33	60	0.017
Positive	58	38.4	49	9		10	48
Age (years)
≤35	35	17.9	30	5	NS	9	26	NS
>35	161	82.1	119	42		54	107

NS: not significant; HPF: high-power field. The value was determined using the test. Significant values are shown with bold font. The number of patients is less than 196 because of missing data. Age (range: 23–66 y, median: 42 y).