β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

Table 4

Univariate and multivariate analysis of factors associated with DFS and OS for patients with CC.

Variable	5-year DFS				5-year OS
	Univariate	Multivariate			Univariate	Multivariate
			HR	95% CI			HR	95% CI
FIGO stage
IA	<0.001	NS			0.002	NS
IB1, IIA1
IB2, IIA2
IIB
Parametrial invasion
Negative	0.002	NS			0.007	NS
Positive
Surgical margin involved
No	0.008	NS			0.036	NS
Yes
Lymph node metastasis
Negative	<0.001	<0.001	5.029	2.623–9.645	<0.001	<0.001	5.058	2.524–10.137
Positive
Tumor size (cm)
≤4	<0.001	NS			0.001	NS
>4
β-Catenin
Negative	0.001	0.035	2.588	1.071–6.251	0.002	0.031	2.873	1.102–7.492
Positive

DFS: disease-free survival; OS: overall survival; HR: hazard ratio; CI: confidence interval; NS: not significant; HPF: high-power field. Significant values are shown in bold font. indicates that risk for recurrence/death increased; indicates that risk for recurrence/death decreased. Univariate and multivariate analyses and Cox proportional hazards regression model. Variables associated with survival by univariate analysis were adopted as covariates in multivariate analyses.