Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study

Table 1

The differences in parameters before operation and 1, 3, and 6 months after operation.

Parameters	Before operation	After operation			value	value
		1 month	3 months	6 months
UCVA (logMAR)						0.734
LASIK-ACXL	1.06 ± 0.20	−0.06 ± 0.08	−0.14 ± 0.06	−0.17 ± 0.04	<0.001
LASIK-only	1.00 ± 0.21	−0.12 ± 0.05	−0.15 ± 0.07	−0.18 ± 0.04	<0.001
CDVA (logMAR)						0.176
LASIK-ACXL	−0.17 ± 0.06	−0.14 ± 0.06	−0.17 ± 0.07	−0.18 ± 0.03	0.134
LASIK-only	−0.18 ± 0.06	−0.17 ± 0.04	−0.17 ± 0.04	−0.18 ± 0.03	0.007
Sphere (D)						0.063
LASIK-ACXL	−6.17 ± 1.89	0.15 ± 0.45	0.20 ± 0.45	0.18 ± 0.18	<0.001
LASIK-only	−5.61 ± 2.81	0.10 ± 0.27	0.13 ± 0.52	0.14 ± 0.16	<0.001
Cylinder (D)						0.582
LASIK-ACXL	−0.80 ± 1.00	−0.03 ± 0.22	−0.05 ± 0.19	−0.09 ± 0.24	<0.001
LASIK-only	−0.65 ± 0.99	−0.02 ± 0.34	−0.03 ± 0.27	−0.04 ± 0.18	<0.001
MRSE (D)						0.313
LASIK-ACXL	−6.54 ± 2.03	0.10 ± 0.58	−0.10 ± 0.43	−0.05 ± 0.33	<0.001
LASIK-only	−5.95 ± 2.33	−0.05 ± 0.69	−0.05 ± 0.44	−0.02 ± 0.42	<0.001
Mean K (D)						0.927
LASIK-ACXL	43.98 ± 1.69	39.45 ± 1.54	39.59 ± 1.68	39.54 ± 1.67	<0.001
LASIK-only	43.66 ± 1.78	39.48 ± 1.84	39.65 ± 2.01	39.60 ± 2.11	<0.001
TCT (µm)						0.844
LASIK-ACXL	524.52 ± 25.95	449.76 ± 41.56	440.19 ± 29.35	438.42 ± 27.40	<0.001
LASIK-only	525.56 ± 25.99	440.64 ± 33.65	435.14 ± 26.99	437.38 ± 24.37	<0.001
ECD (cell/mm^2)						0.869
LASIK-ACXL	2732.38 ± 110.37	2809.64 ± 145.88	2712.49 ± 128.34	2698.17 ± 137.09	0.295
LASIK-only	2726.75 ± 107.45	2763.45 ± 129.76	2796.57 ± 139.18	2702.96 ± 136.95	0.320

value: compared between preoperation and 6 months after operation.
value: compared between two groups at 6 months after operation.
ACXL, accelerated corneal collagen cross-linking; UDVA, uncorrected distance visual acuity; CDVA, corrected distance visual acuity; MRSE, manifest refraction spherical equivalent; , keratometry; TCT, thinnest corneal thickness; ECD, endothelial cell density.