Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance

Figure 3

The ADAMTS8 mRNA expression and methylation status prior to and following treatment with ADC. (a) ADAMTS8 mRNA expression level in four gastric cancer cell lines prior to and following treatment with ADC (). (b) ADAMTS8 mRNA expression level in MKN45 cell line prior to and following treatment with different concentrations of ADC. (c) Methylation of ADAMTS8 following treatment with ADC by MSP analysis. (d) ADAMTS8 CpG methylation status following treatment with ADC by BGS.

(a)

(b)

(c)

(d)