Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance

Table 2

Correlation of ADAMTS8 mRNA expression and clinicopathological characteristics of gastric cancer samples.

Variable	Patients ()	ADAMTS8 expression relative to GAPDH	value
Age (years)
<65	40	0.290 ± 0.102
≥65	26	0.267 ± 0.115	0.405
Gender
Male	45	0.285 ± 0.112
Female	21	0.273 ± 0.099	0.674
Tumor differentiation
Well/moderate	33	0.267 ± 0.111
Poor	33	0.295 ± 0.103	0.289
Invasive depth
T1 + T2	22	0.329 ± 0.101
T3 + T4	44	0.257 ± 0.103	0.009
Tumor location
Upper + middle	13	0.300 ± 0.110
Lower	53	0.276 ± 0.107	0.481
Size (cm)
<3	28	0.287 ± 0.128
≥3	38	0.277 ± 0.091	0.713
Lymph node metastasis
No	20	0.402 ± 0.064
Yes	46	0.229 ± 0.075	<0.001

; ADAMTS8: ADAM metallopeptidase with thrombospondin type 8 motif.