Luteolin Prevents H₂O₂-Induced Apoptosis in H9C2 Cells through Modulating Akt-P53/Mdm2 Signaling Pathway

Figure 7

Luteolin increased the mRNA expression of Mdm2. H9C2 cells were preincubated with/without luteolin (10 μM)/quercetin (10 μM) for 6 h and then treated with 100 μM H₂O₂ for 1 h. Cells were extracted, cDNA was synthesized, and the Mdm2 gene mRNA amount was assessed by quantitative real-time PCR and normalized to the β-actin. Data were expressed as mean ± SD. and versus control; versus model.