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BioMed Research International
Volume 2016 (2016), Article ID 5139651, 11 pages
http://dx.doi.org/10.1155/2016/5139651
Clinical Study

Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis

1Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China
2Xinjiang Medical University, Urumqi, Xinjiang 830054, China
3Department of Pathology, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Received 12 April 2016; Revised 18 June 2016; Accepted 20 June 2016

Academic Editor: Taiyoun Rhim

Copyright © 2016 Guitao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis. Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A, ) and the VAWI group (group B, ). At the same time, we selected the age-matched healthy patients (). We applied the combined protein chip with SELDI-TOF-MS to carry out the serum analysis. The data were analyzed throughout data preprocessing, difference in PEAK screening, hierarchical cluster analysis, and Principal Component Analysis (PCA). We built decision tree model and predict the difference between the PEAK corresponding proteins. Results. The proteins peaks corresponding to name, predicted protein, and gene name were as follows: M2001_69, amyloid beta a4 protein, APP, and M2017_02, amyloid beta a4 protein, APP. The different expression of proteins in patients with silicosis was found before and after with VAWI treatment. The predicted proteins were as follows: M1982_50, amyloid beta a4 protein, APP; M3164_50, fibrinogen alpha chain frag, FGA; M3379_28, fibrinogen alpha chain frag, FGA; and so on. Conclusion. VAWI presented curative effect on patients with silicosis fibrosis via the alternation of proteins expression in serum.