Detecting Susceptibility to Breast Cancer with SNP-SNP Interaction Using BPSOHS and Emotional Neural Networks

Table 1

SNP interactions about breast cancer.

SNP (gene) (chromosome/position)	SNP type	Case number	Control number	Difference	Odds ratio	95% CI	value
rs3020314 (ESR1) (6/152270672); rs500760 (PGR) (11/100909991)	CC-; AA	1230	1404	174	0.836	0.7644–0.9135	0.001
rs3020314 (ESR1) (6/152270672); rs2017591 (STS) (X/7158114)	CC-; TC	984	1152	168	0.818	0.7436–0.9008	0.003
rs3020314 (ESR1) (6/152270672); rs2077647 (ESR1) (6/152129077)	CT-; GG	1055	1213	158	0.835	0.7602–0.9170	0.008
rs500760 (PGR) (11/100909991); rs2017591 (STS) (X/7158114)	AG-; CC	1326	1476	150	0.862	0.7896–0.9404	0.001
rs2077647 (ESR1) (6/152129077); rs2017591 (STS) (X/7158114)	AG-; TC	1117	1263	146	0.851	0.7762–0.9333	0.040
rs3020314 (ESR1) (6/152270672); rs660149 (PGR) (11/100934314); rs11571171 (PGR) (11/100974887)	CT-; CC-; TT	602	509	93	1.208	1.0657–1.3687	0.003
rs3020314 (ESR1) (6/152270672); rs500760 (PGR) (11/100909991); rs2017591 (STS) (X/7158114)	CC-; AA-; TC	571	699	128	0.793	0.7048–0.8929	0.012
rs6269 (COMT) (22/19949952); rs2175898 (ESR1) (6/152196952); rs660149 (PGR) (11/100934314)	AA-; AG-; CC	1035	1158	123	0.866	0.7877–0.9522	0.003
rs3020314 (ESR1) (6/152270672); rs1543404 (ESR1) (6/152428838); rs2747652 (ESR1) (6/152437016); rs9340799 (ESR1) (6/152163381); rs1709182 (ESR1) (6/152175357); rs9478249 (ESR1) (6/152194431); rs660149 (PGR) (11/100934314); rs11571171 (PGR) (11/100974887); rs858518 (SHBG) (17/7533025); rs858524 (SHBG) (17/7511287); rs2017591 (STS) (X/7158114)	CT-; TC-; CT-; AG-; TT-; TG-; CC-; TT-; TC-; AG-; TT	7	1	6	7.01	0.8800–151.68	0.034