A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome
Table 6
Univariable and multivariable analysis for primary endpoint.
Variables
Crude HR (95% CI)
value
Adjusted HR (95% CI)
value
Treatment strategy
Monotherapy
ref
ref
None
3.31
(0.64–17.22)
0.156
4.19
(0.54–32.31)
0.169
Dual therapy
1.12
(0.24–5.28)
0.886
1.66
(0.23–12.03)
0.614
Triple therapy
1.45
(0.33–6.51)
0.624
2.88
(0.41–20.35)
0.290
Quadruple therapy
1.07
(0.18–6.39)
0.944
2.01
(0.22–18.23)
0.535
Age (year)
1.01
(0.98–1.04)
0.475
1.00
(0.95–1.04)
0.831
Sex
Female
ref
ref
Male
0.96
(0.37–2.51)
0.937
1.43
(0.39–5.22)
0.587
Baseline maximum aortic diameter (cm)
2.11
(1.38–3.23)
<0.001
2.91
(1.70–4.99)
<0.001
Current smoker
1.13
(0.55–2.35)
0.740
0.89
(0.33–2.39)
0.810
BMI
1.00
(0.93–1.08)
0.974
0.98
(0.89–1.08)
0.679
Comorbidities (before index day 1 year)
Hyperlipidemia
1.15
(0.47–2.82)
0.763
1.33
(0.42–4.18)
0.627
Hypertension
0.95
(0.22–4.00)
0.940
0.29
(0.05–1.71)
0.169
Diabetes mellitus
1.06
(0.40–2.80)
0.901
1.05
(0.32–3.44)
0.931
COPD
1.63
(0.67–4.00)
0.283
1.03
(0.26–4.02)
0.966
Heart failure
2.04
(0.71–5.85)
0.187
0.97
(0.22–4.28)
0.964
Coronary artery disease
1.68
(0.69–4.10)
0.258
2.06
(0.49–8.70)
0.326
Cerebrovascular disease
0.97
(0.34–2.78)
0.952
0.46
(0.13–1.66)
0.237
Chronic kidney disease
1.90
(0.77–4.65)
0.161
2.16
(0.68–6.84)
0.193
Cancer
1.55
(0.47–5.17)
0.472
2.10
(0.48–9.25)
0.326
Poor blood pressure and heart rate control
Poor blood pressure control
0.94
(0.36–2.46)
0.892
0.63
(0.20–1.99)
0.431
Poor heart rate control
0.99
(0.35–2.85)
0.990
0.68
(0.16–2.88)
0.600
HR: hazard ratio; CI: confidence interval; BMI: body mass index; COPD: chronic obstructive pulmonary disease. Adjusted for treatment strategy, age, sex, initial maximum aortic diameter, current smoker, BMI, all of comorbidity, poor blood pressure, and poor heart rate control. .
