Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review

Table 5

Characteristics of the patients with concomitant Crohn’s disease and Hashimoto’s thyroiditis.

Case	(Year)	Gender	Age at diagnosis of CD (years)	Age at diagnosis of HT (years)	CD prior to HT	Thyroid function tests; (TSH: μU/mL, freeT3: pg/mL, freeT4: ng/dL)	Complications	Reference
1	(1988)	M	17	44	+	Hypothyroidism (TSH 5.3); → normalization		[33]
2	(1988)	F	26	43	+	Normal		[33]
3	(1988)	F	43	55	+	Hypothyroidism (TSH 9.6)		[33]
4	(2002)	F	53	46	−	?	Sjögren’s syndrome	[34]
5	(2005)	F	16	24	+	Thyrotoxicosis (TSH 0.036, freeT3 13.2, freeT4 5.6); → normalization		[22]
6	(2006)	F	26	26	Sim	Hypothyroidism (TSH 3.90, freeT4 1.39); → normalization	Turner syndrome	[35]
7	(2008)	F	15	15	Sim	Thyrotoxicosis (TSH < 0.05, free T4 2.7); → subsequent hypothyroidism	Beta-thalassemia	[36]
8	(2012)	F	14	10	−	Hypothyroidism; → normalization		[37]
9	(2012)	M	10	10	Sim	Thyrotoxicosis (TSH 0.05, freeT4 31.5)	Bardet-Biedl syndrome; Primary sclerosing cholangitis	[38]
10	(2013)	M	33?	35?	+	Thyrotoxicosis?	Primary biliary cirrhosis; Familial CD	[39]

CD: Crohn’s disease; HT: Hashimoto’s thyroiditis; F: female; M: male; Sim: simultaneous.
Japanese-language literature.