Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 5302069, 8 pages
http://dx.doi.org/10.1155/2016/5302069
Research Article

Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock

1Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
2College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

Received 29 February 2016; Revised 6 June 2016; Accepted 10 July 2016

Academic Editor: Hartmut Jaeschke

Copyright © 2016 Fu-Chao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. F. Johnson Jr. and J. Gustin, “Acute lung injury and acute respiratory distress syndrome requiring tracheal intubation and mechanical ventilation in the intensive care unit: impact on managing uncertainty for patient-centered communication,” American Journal of Hospice and Palliative Medicine, vol. 30, no. 6, pp. 569–575, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. R. R. Hukkanen, H. D. Liggitt, R. D. Murnane, and C. W. Frevert, “Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation,” Toxicologic Pathology, vol. 37, no. 6, pp. 799–804, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Barlos, E. A. Deitch, A. C. Watkins et al., “Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 296, no. 3, pp. L404–L417, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. C. Reino, V. Pisarenko, D. Palange et al., “Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice,” PLoS ONE, vol. 6, no. 8, Article ID e14829, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Schröder, R. N. Pierson III, B.-N. H. Nguyen et al., “CCR5 blockade modulates inflammation and alloimmunity in primates,” Journal of Immunology, vol. 179, no. 4, pp. 2289–2299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Akahori, M. Sho, H. Kashizuka, T. Nomi, H. Kanehiro, and Y. Nakajima, “A novel CCR5/CXCR3 antagonist protects intestinal ischemia/reperfusion injury,” Transplantation Proceedings, vol. 38, no. 10, pp. 3366–3368, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Grommes, M. Drechsler, and O. Soehnlein, “CCR5 and FPR1 mediate neutrophil recruitment in endotoxin-induced lung injury,” Journal of Innate Immunity, vol. 6, no. 1, pp. 111–116, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Széles, D. Töröcsik, and L. Nagy, “PPARγ in immunity and inflammation: cell types and diseases,” Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1771, no. 8, pp. 1014–1030, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Wang, L. Liu, Y. Zhang et al., “Activation of PPARγ attenuates LPS-induced acute lung injury by inhibition of HMGB1-RAGE levels,” European Journal of Pharmacology, vol. 726, no. 1, pp. 27–32, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. P. Lakshmi, A. T. Reddy, Y. Zhang et al., “Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD),” The Journal of Biological Chemistry, vol. 289, no. 10, pp. 6383–6393, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. F.-C. Liu, Y.-F. Tsai, and H.-P. Yu, “Maraviroc attenuates trauma-hemorrhage-induced hepatic injury through PPAR gamma-dependent pathway in rats,” PLoS ONE, vol. 8, no. 10, article e78861, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Kakuta, M. Okumi, S. Miyagawa et al., “Blocking of CCR5 and CXCR3 suppresses the infiltration of macrophages in acute renal allograft rejection,” Transplantation, vol. 93, no. 1, pp. 24–31, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. F.-C. Liu, Y.-J. Day, C.-H. Liao, J.-T. Liou, C.-C. Mao, and H.-P. Yu, “Hemeoxygenase-1 upregulation is critical for sirtinol-mediated attenuation of lung injury after trauma-hemorrhage in a rodent model,” Anesthesia and Analgesia, vol. 108, no. 6, pp. 1855–1861, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Zallen, E. E. Moore, J. L. Johnson, D. Y. Tamura, D. J. Ciesla, and C. C. Silliman, “Posthemorrhagic shock mesenteric lymph primes circulating neutrophils and provokes lung injury,” Journal of Surgical Research, vol. 83, no. 2, pp. 83–88, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. L. H. Toledo-Pereyra and S. Suzuki, “Neutrophils, cytokines, and adhesion molecules in hepatic ischemia and reperfusion injury,” Journal of the American College of Surgeons, vol. 179, no. 6, pp. 758–762, 1994. View at Google Scholar · View at Scopus
  16. J.-T. Hsu, W.-H. Kan, C.-H. Hsieh, M. A. Choudhry, K. I. Bland, and I. H. Chaudry, “Role of extracellular signal-regulated protein kinase (ERK) in 17β-estradiol-mediated attenuation of lung injury after trauma-hemorrhage,” Surgery, vol. 145, no. 2, pp. 226–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. A. Fielding, R. M. McLoughlin, L. McLeod et al., “IL-6 regulates neutrophil trafficking during acute inflammation via STAT3,” The Journal of Immunology, vol. 181, no. 3, pp. 2189–2195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. H. Meng, K. Dyer, T. R. Billiar, and D. J. Tweardy, “Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock,” American Journal of Physiology—Cell Physiology, vol. 280, no. 2, pp. C343–C351, 2001. View at Google Scholar · View at Scopus
  19. T. Hoshino, M. Okamoto, Y. Sakazaki, S. Kato, H. A. Young, and H. Aizawa, “Role of proinflammatory cytokines IL-18 and IL-1β in bleomycin-induced lung injury in humans and mice,” American Journal of Respiratory Cell and Molecular Biology, vol. 41, no. 6, pp. 661–670, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. K. E. Lunsford, B. J. Baird, G. D. Sempowski et al., “Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury,” Transplantation, vol. 95, no. 8, pp. 1000–1007, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. K. R. Coulter, M. D. Wewers, M. P. Lowe, and D. L. Knoell, “Extracellular regulation of interleukin (IL)-1β through lung epithelial cells and defective IL-1 type II receptor expression,” American Journal of Respiratory Cell and Molecular Biology, vol. 20, no. 5, pp. 964–975, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. F.-S. Lin, C.-C. Lin, C.-S. Chien, S.-F. Luo, and C.-M. Yang, “Involvement of p42/p44 MAPK, JNK, and NF-κβ in IL-1β-induced ICAM-1 expression in human pulmonary epithelial cells,” Journal of Cellular Physiology, vol. 202, no. 2, pp. 464–473, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Pozo-Balado, I. Rosado-Sánchez, G. Méndez-Lagares et al., “Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects,” Clinical Microbiology and Infection, vol. 22, no. 5, pp. 461.e1–461.e5, 2016. View at Publisher · View at Google Scholar
  24. J. Díaz-Delfín, P. Domingo, M. Giralt, and F. Villarroya, “Maraviroc reduces cytokine expression and secretion in human adipose cells without altering adipogenic differentiation,” Cytokine, vol. 61, no. 3, pp. 808–815, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Rossi, M. Lichtner, A. de Rosa et al., “In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells,” Clinical and Experimental Immunology, vol. 166, no. 2, pp. 184–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Francisci, E. Falcinelli, S. Baroncelli et al., “Potential anti-inflammatory effects of maraviroc in HIV-positive patients: a pilot study of inflammation, endothelial dysfunction, and coagulation markers,” Scandinavian Journal of Infectious Diseases, vol. 46, no. 6, pp. 466–470, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Martin-Blondel, D. Brassat, J. Bauer, H. Lassmann, and R. S. Liblau, “CCR5 blockade for neuroinflammatory diseases-beyond control of HIV,” Nature Reviews Neurology, vol. 12, no. 2, pp. 95–105, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. N. F. Russkamp, R. Ruemmler, J. Roewe, B. B. Moore, P. A. Ward, and M. Bosmann, “Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin,” The FASEB Journal, vol. 29, no. 9, pp. 3762–3772, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. J. N. Feige, L. Gelman, L. Michalik, B. Desvergne, and W. Wahli, “From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions,” Progress in Lipid Research, vol. 45, no. 2, pp. 120–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Suzuki, T. Kawasaki, M. A. Choudhry, and I. H. Chaudry, “Role of PPARγ in the salutary effects of 17β-estradiol on kupffer cell cytokine production following trauma-hemorrhage,” Journal of Cellular Physiology, vol. 226, no. 1, pp. 205–211, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Zingarelli, P. W. Hake, M. O'Connor et al., “Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor γ,” Critical Care Medicine, vol. 37, no. 6, pp. 1978–1987, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Drosatos, R. S. Khan, C. M. Trent et al., “Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice,” Circulation: Heart Failure, vol. 6, no. 3, pp. 550–562, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Jung, S. Song, and C. Choi, “Peroxisome proliferator activated receptor γ agonists suppress TNFα-induced ICAM-1 expression by endothelial cells in a manner potentially dependent on inhibition of reactive oxygen species,” Immunology Letters, vol. 117, no. 1, pp. 63–69, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Yao, D. Pan, Y. Zhao et al., “Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor γ-mediated attenuation of the nuclear factor-κβ pathway,” Immunology, vol. 143, no. 2, pp. 241–257, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. D. M. Hasan, R. M. Starke, H. Gu et al., “Smooth muscle peroxisome proliferator-activated receptor γ plays a critical role in formation and rupture of cerebral aneurysms in mice in vivo,” Hypertension, vol. 66, no. 1, pp. 211–220, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Singh, K. I. Chaudry, L. C. Chudler, and I. H. Chaudry, “Depressed gut absorptive capacity early after trauma-hemorrhagic shock. Restoration with diltiazem treatment,” Annals of Surgery, vol. 214, no. 6, pp. 712–718, 1991. View at Publisher · View at Google Scholar · View at Scopus
  37. J. P. Tao, Q. Q. Huang, H. Q. Huang et al., “Effects of goal-directed fluid therapy with different lactated ringer’s: hydroxyethyl starch ratios in hemorrhagic shock dogs,” Genetics and Molecular Research, vol. 14, no. 2, pp. 6649–6663, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. S. L. Muir, L. B. Sheppard, A. Maika-Wilson et al., “A comparison of the effects of intraosseous and intravenous 5% albumin on infusion time and hemodynamic measures in a swine model of hemorrhagic shock,” Prehospital and Disaster Medicine, vol. 31, no. 4, pp. 436–442, 2016. View at Publisher · View at Google Scholar
  39. Y. Benhamou, J. Favre, P. Musette et al., “Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice,” Critical Care Medicine, vol. 37, no. 5, pp. 1724–1728, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. B. Blasiole, H. Bayr, V. A. Vagni et al., “Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice,” Anesthesiology, vol. 118, no. 3, pp. 649–663, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. V. R. Yadav, A. Hussain, J. Xie, S. Kosanke, and V. Awasthi, “The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model,” Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 23, article 8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. C.-T. Wu, H.-P. Yu, C.-Y. Chung, Y.-T. Lau, and S.-K. Liao, “Attenuation of lung inflammation and pro-inflammatory cytokine production by resveratrol following trauma-hemorrhage,” Chinese Journal of Physiology, vol. 51, no. 6, pp. 363–368, 2008. View at Google Scholar · View at Scopus
  43. Y.-F. Tsai, H.-P. Yu, P.-J. Chung et al., “Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4,” Free Radical Biology & Medicine, vol. 89, pp. 387–400, 2015. View at Publisher · View at Google Scholar · View at Scopus