Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Table 3

Reactions carried out by the human CYP1A1 depending on the type of substrate.

Origin	Category compound	Type of reaction	Source
Synthetic compounds	Polycyclic aromatic hydrocarbons	Oxidation Epoxidation	[80, 81]
	Nitrosamides	Nitroreduction	[82, 83]
	Arylamines	N-hydroxylation Oxidation	[80, 81]
	Benzotriazole	Oxidation	[84]
	Heterocyclic amines	N-hydroxylation Oxidation	[80, 81]
	Nitroarenes	Nitroreduction	[85]
	Azoaromatic amines	Oxidation	[80, 81]
Natural compounds	Difuranocumarin	Epoxidation Oxidation	[86]
	Nefrotoxin	Hydroxylation	[87]
	Flavonoid	Hydroxylation O-demethylation	[88, 89]
Drugs	Ellipticin	Oxidation	[90]
	Omeprazol	ND	[91]
	Oltipraz	ND	[92]
Endogenous substrates	Arachidonic acid	Hydroxylation	[93]
	Melatonin	Hydroxylation	[94]
	Eicosapentaenoic acid	Epoxidation	[93]
	Stradiol	Hydroxylation	[95]