Review Article
Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
Table 3
Reactions carried out by the human CYP1A1 depending on the type of substrate.
| Origin | Category compound | Type of reaction | Source |
| Synthetic compounds | Polycyclic aromatic hydrocarbons | Oxidation Epoxidation | [80, 81] | Nitrosamides | Nitroreduction | [82, 83] | Arylamines | N-hydroxylation Oxidation | [80, 81] | Benzotriazole | Oxidation | [84] | Heterocyclic amines | N-hydroxylation Oxidation | [80, 81] | Nitroarenes | Nitroreduction | [85] | Azoaromatic amines | Oxidation | [80, 81] |
| Natural compounds | Difuranocumarin | Epoxidation Oxidation | [86] | Nefrotoxin | Hydroxylation | [87] | Flavonoid | Hydroxylation O-demethylation | [88, 89] |
| Drugs | Ellipticin | Oxidation | [90] | Omeprazol | ND | [91] | Oltipraz | ND | [92] |
| Endogenous substrates | Arachidonic acid | Hydroxylation | [93] | Melatonin | Hydroxylation | [94] | Eicosapentaenoic acid | Epoxidation | [93] | Stradiol | Hydroxylation | [95] |
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