Animal model Development stage Spatial localization Detection method Reference Human 16–36 gestation weeks Not determined- PCR [96 ] 50–60 gestation weeks Hepatic tissue BZROD−1 ) [97 ] 74–145 gestation days Day 87: kidney PCR: southern blot [98 ] Mouse E17 Not determined- PCR [96 , 99 ] E7-E14 E7: extraembryonic ectoderm and mesoderm lacZ reporter with the promoter of CYP1A1 [100 ] Rat 15–29 gestation days D15: liver PCR [98 ] Chicken 4–15 incubation days D4–D7: embryonic pool EROD−1 )−1 )−1 ) [101 ] 17 incubation days Liver Run-on [102 ] 18 incubation days Liver EROD−1 )−1 ) [103 ] 10 incubation days Liver q-PCR [104 ] Zebra Fish 8–128 hours after fertilization (hpf) 8 hpf: germs layers EROD in vivo−1 ) [105 ] 48–120 hpf Embryonic pool q-PCR EROD in vivo−1 ) [106 ] 4–8 days after fertilization Not determined EROD in vivo−1 larva−1 ) [107 ] Medaka fish 8 hpf Not determined EROD in vivo [108 ] 50–245 hpf Gallbladder EROD in vivo [109 ]
