Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma
Cisplatin increased -catenin expression levels and mediated nuclear translocation in OSCC cell lines. (a) Western blot analysis showed protein expression levels of -catenin were correlated with the cisplatin treatment. (b) Confocal microscopy showed cisplatin stimulated nuclear translocation of -catenin (indicated by the arrow). (A–D) SCC-25 cells treated with cisplatin (0, 1, 2, and 4 μg/mL) for 24 h; (E–H) SCC-15 cells treated with cisplatin (1 μg/mL) for 0, 24, 48, and 72 h (magnification: 200х).