Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma

Figure 4

-catenin knockdown increased sensitivity to cisplatin in vivo. (a) Photographs of tumors (A: OX-NC, B: OX, C: LX-NC, and D: LX). (b) Tumor sizes were measured from day 14 until mice were killed. When tumor volumes reached 100 to 150 mm³, mice were injected with 4 mg/kg cisplatin through the tail vein. (c) Tumor weight was measured at the end of the experiment. The tumor weight was significantly reduced in mice treated with OSCC cells with -catenin knockdown after cisplatin treatment, whereas the tumor size continuously increased with the overexpression of -catenin indicating promoted tumor growth. ; .

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