Relationship between Antibody Levels, IgG Binding to Plasmodium falciparum-Infected Erythrocytes, and Disease Outcome in Hospitalized Urban Malaria Patients from Dakar, Sénégal

Figure 2

IgG antibodies levels against whole parasite extract antigens (a) and recombinants proteins (b) in survivors and fatal CM patients. Scatter plot of IgG responses to whole parasite extracts antigens (a) and recombinant proteins (b). Comparison between surviving cerebral malaria patients (SCM; ; open circles) and fatal cerebral malaria patients (FCM; ; black circles) for each antigen. Horizontal blue bar indicates medians of OD ratio value. The Mann-Whitney rank test was employed for between-groups comparison for each antigen. IgG levels were highest in surviving CM group for P. falciparum schizont extract, iRBC membrane, PfEB200, and PfEMP3/5. Significant values are included ().

(a)

(b)