Evaluation of Hepatotoxicity with Treatment Doses of Flucytosine and Amphotericin B for Invasive Fungal Infections

Figure 6

The effect of flucytosine and amphotericin B coadministration on ultrastructural changes in the livers of experimental mice: (A) control group; (B) 50 mg/kg flucytosine + 300 μg/kg amphotericin B group; (C) 100 mg/kg flucytosine + 600 μg/kg amphotericin B group; (D) 150 mg/kg flucytosine + 900 μg/kg amphotericin B group. (1, 2) Detail of activated Kuppfer cells and perisinusoidal fibrosis. N: nucleus, CK: Kuppfer cells, S: sinusoids, C: collagen, and arrow: dilated bile canaliculi.