Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A

Table 1

Characteristics of studies included in the meta-analysis.

Study	Country	Ethnicity	⁢ Patients		Controls		Typing methods	⁢Significant association with HLA-A ()		Quality score
			Clinical types	Number	Types	Number		Positive	Negative
Ramire et al., 2016 [33]	Brazil	American	27 localized, 78 generalized, 11 nonclassified	116	NCs	243	PCR-SSO	A02, 25, 34	A01, 03, 11, 23, 24, 26, 29, 30, 31, 32, 33, 36, 66, 68, 69, 80	8
Wang et al., 2014 [10]	China	Asian	Unknown	97	NCs	72	PCR-SSP		A02	7
Singh et al., 2012 [32]	India	Asian	411 localized, 1347 generalized	1758	NCs	1310	PCR-SSOP	A02, 26, 31, 33	A68	7
Akay et al., 2010 [11]	Turkey	Asian	Unknown	52	NCs	100	LCT	A24, 30	A01, 02, 03, 04, 09, 10, 11, 23, 25, 26, 29, 32, 66, 68	9
Wang et al., 2007 [12]	China	Asian	34 generalized	34	NCs	102	PCR-SSP	A30		9
Abanmi et al., 2006 [13]	Saudi Arabia	Asian	34 generalized, 6 universal	40	NCs	40	LCT	A09	A01, 02, 03, 10, 11, 19, 28, 36, 38, 43, 80	9
Zhang et al., 2004 [14]	China	Asian	93 localized, 94 generalized	187	NCs	252	PCR-SSP	A25, 30, 31, 36, 66	A01, 02, 26, 43	9
Taştan et al., 2004 [15]	Turkey	Asian	Unknown	33	NCs	100	LCT	A24	A01, 02, 03, 11, 23, 26, 29, 30, 31, 32, 33, 68	5
Wang et al., 2000 [16]	China	Asian	40 vulgaris, 22 focal, 8 acrofacial, 25 segmental	95	NCs	100	LCT	A02, 10, 28	A01, 03, 09, 11	9
Valsecchi et al., 1995 [18]	Italy	European	20 vulgaris, 3 focal, 7 acrofacial, 3 acral	33	NCs	443	LCT		A01, 02, 03, 09, 10, 11, 28, 29, 30, 31, 32, 33	6
Venkataram et al., 1995 [17]	Oman	Asian	29 focal, 21 acrofacial	50	NCs	92	LCT		A30	7
Al-Fouzan et al., 1995 [19]	Kuwait	Asian	40 nonsegmental	40	NCs	40	LCT	A19		9
Venneker et al., 1993 [20]	Dutch	European	48 generalized	48	NCs	703	LCT		A02	6
Schallreuter et al., 1993 [21]	German	European	57 vulgaris, 13 focal, 22 acrofacial, 7 universal, 3 segmental	102	NCs	400	LCT	A01, 02		9
Ando et al., 1993 [22]	Japan	Asian	39 nonsegmental	39	NCs	544	LCT		A02, 03, 11, 24, 26, 31, Aw33	5
Orecchia et al., 1992 [23]	Italy	European	65 vulgaris, 13 focal, 7 acrofacial, 8 acral	93	NCs	388	LCT	A30	A03, 09	6
Dai et al., 1990 [24]	China	Asian	30 focal, 40 generalized, 30 segmental	100	NCs	116	LCT	A02, 03	A01, 09, 10, 11, 28	6
Metzker et al., 1980 [25]	Israel	Mixed	Unknown	77	NCs	462	LCT	A02, 11	A01, 03, 09, 10, 28, 29, Aw19	5
Kachru et al., 1978 [26]	America	American	Unknown	48	NCs	107	LCT	A01, 02, 10, Aw31	A03, 09, 11, 28, 29, Aw19, 23, 24, 30, 32, 33	7

HLA: human leukocyte antigen, Number: number of subjects, NCs: normal controls, LCT: lymphocytotoxicity test, PCR-SSP: polymerase chain reaction sequence-specific primers, PCR-SSO: polymerase chain reaction sequence-specific oligonucleotides, and PCR-SSOP: polymerase chain reaction sequence-specific oligonucleotide probes.