Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products

Figure 6

Effects of an ERS inhibitor on the protein expression of HMG-CoAR, LDLr, SREBP-2, ABCA1, and LXR in HK-2 cells. The protein level was examined via Western blot analysis after cells were incubated with CML, CML plus 4-PBA, or 4-PBA alone for 24 h. The histogram represents the means ± SD of the densitometric scans for proteins from 3 experiments, normalized by comparison with β-actin and expressed as a percentage of the control (a). Nuclear nSREBP-2 protein level was normalized by comparison with histone-H (b). , compared with the Ctr; , compared with CML.

(a)

(b)