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BioMed Research International
Volume 2016, Article ID 5478394, 6 pages
Research Article

Pulmonary Function and Arterial Stiffness in Chronic Heart Failure

1Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China
2Intensive Care Unit, Zhejiang Provincial People’s Hospital, 158 Shangtang Road, Hangzhou 310014, China

Received 30 September 2016; Revised 28 November 2016; Accepted 30 November 2016

Academic Editor: Fabrizio Montecucco

Copyright © 2016 Li Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1 to FVC ratio (FEV1/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV1 (, ). Multiple stepwise regression analyses showed that ARB and FEV1 () were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary.