Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities

Table 2

Correlation of clotting factor activity and serum levels with routine blood tests. Table shows Spearman’s rank correlation coefficient rho with 95% confidence interval (CI). INR: International Normalized Ratio; PTT: Partial Thromboplastin Time.

	Fibrinogen	Calcium	FII	FV	FVII	FVIII	FIX	FX	FXI	FXII	FXIII
INR	−.60 (−.78 to −.33)	−.32 (−.53 to −.06)	−.61 (−.77 to −.38)	−.67 (−.81 to −.47)	−.74 (−.87 to −.56)	−.12 (−.44 to .22)	−.43 (−.69 to −.13)	−.49 (−.70 to −.24)	−.35 (−.61 to −.06)	−.32 (−.55 to −.06)	−.37 (−.59 to −.12)
PTT	−.28 (−.50 to .00)	−.27 (−.51 to .03)	−.44 (−.64 to −.17)	−.45 (−.67 to −.17)	−.32 (−.54 to −.05)	−.72 (−.85 to −.53)	−.55 (−.74 to −.29)	−.36 (−.62 to −.07)	−.62 (−.77 to −.40)	−.52 (−.73 to −.25)	−.21 (−.45 to .05)
Platelet count	.31 (.04 to .54)	.29 (.02 to .54)	.42 (.17 to .62)	.15 (−.10 to .36)	.34 (.07 to .56)	.25 (−.04 to .51)	.31 (.05 to .52)	.38 (.13 to .57)	.41 (.15 to .62)	.16 (−.14 to .40)	.38 (.09 to .64)
Hemoglobin	.40 (.17 to .60)	.56 (.32 to .74)	.42 (.19 to .62)	.41 (.15 to .61)	.34 (.07 to .57)	.20 (−.07 to .47)	.52 (.32 to .69)	.59 (.39 to .75)	.43 (.21 to .62)	.36 (.09 to .60)	.41 (.13 to .63)
Lactate	−.29 (−.56 to .01)	−.31 (−.54 to −.03)	−.26 (−.48 to .03)	−.32 (−.55 to −.03)	−.15 (−.42 to .15)	−.07 (−.34 to .25)	−.07 (−.34 to .24)	−.07 (−.33 to .21)	−.06 (−.34 to .29)	−.17 (−.44 to .17)	−.31 (−.55 to −.02)
Base deficit	.37 (.09 to .60)	.58 (.33 to .75)	.46 (.22 to .65)	.61 (.41 to .76)	.33 (.05 to .57)	.15 (−.18 to .44)	.32 (.04 to .58)	.20 (−.03 to .43)	.27 (.01 to .49)	.36 (.09 to .58)	.24 (−.05 to .51)