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BioMed Research International
Volume 2016, Article ID 5634148, 8 pages
http://dx.doi.org/10.1155/2016/5634148
Research Article

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis

1Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea
2Department of Urology, College of Medicine, Chonnam National University, Gwangju, Republic of Korea
3Department of Urology, College of Medicine, Korea University, Seoul, Republic of Korea
4Department of Urology, College of Medicine, Catholic University, Seoul, Republic of Korea
5Department of Urology, National Cancer Center, Goyang, Republic of Korea
6Department of Urology, College of Medicine, Kyungpook National University, Daegu, Republic of Korea
7Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
8Department of Urology, College of Medicine, Hallym University, Chuncheon, Republic of Korea

Received 18 August 2016; Accepted 12 October 2016

Academic Editor: Péter Nyirády

Copyright © 2016 Seok-Soo Byun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer Journal for Clinicians, vol. 65, no. 1, pp. 5–29, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Ljungberg, K. Bensalah, S. Canfield et al., “EAU guidelines on renal cell carcinoma: 2014 update,” European Urology, vol. 67, no. 5, pp. 913–924, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. S. I. Grivennikov, F. R. Greten, and M. Karin, “Immunity, Inflammation, and Cancer,” Cell, vol. 140, no. 6, pp. 883–899, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. S. D. Roxburgh and D. C. McMillan, “Role of systemic inflammatory response in predicting survival in patients with primary operable cancer,” Future Oncology, vol. 6, no. 1, pp. 149–163, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Zahorec, “Ratio of neutrophil to lymphocyte counts—rapid and simple parameter of systemic inflammation and stress in critically ill,” Bratislavske Lekarske Listy, vol. 102, no. 1, pp. 5–14, 2001. View at Google Scholar · View at Scopus
  6. P. H. Gibson, B. L. Croal, B. H. Cuthbertson et al., “Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting,” American Heart Journal, vol. 154, no. 5, pp. 995–1002, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Azab, V. Chainani, N. Shah, and J. T. McGinn, “Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study,” Angiology, vol. 64, no. 6, pp. 456–465, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Hu, L. Lou, J. Ye, and S. Zhang, “Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis,” BMJ Open, vol. 5, no. 4, Article ID e006404, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. M.-X. Li, X.-M. Liu, X.-F. Zhang et al., “Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis,” International Journal of Cancer, vol. 134, no. 10, pp. 2403–2413, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. W.-K. Xiao, D. Chen, S.-Q. Li, S.-J. Fu, B.-G. Peng, and L.-J. Liang, “Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis,” BMC Cancer, vol. 14, no. 1, article 117, pp. 117–126, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Atzpodien, P. Royston, T. Wandert, and M. Reitz, “Metastatic renal carcinoma comprehensive prognostic system,” British Journal of Cancer, vol. 88, no. 3, pp. 348–353, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Donskov and H. von der Maase, “Impact of immune parameters on long-term survival in metastatic renal cell carcinoma,” Journal of Clinical Oncology, vol. 24, no. 13, pp. 1997–2005, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Keizman, M. Ish-Shalom, P. Huang et al., “The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma,” European Journal of Cancer, vol. 48, no. 2, pp. 202–208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Ohno, J. Nakashima, M. Ohori, T. Gondo, T. Hatano, and M. Tachibana, “Followup of neutrophil-to-lymphocyte ratio and recurrence of clear cell renal cell carcinoma,” Journal of Urology, vol. 187, no. 2, pp. 411–417, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Lucca, M. de Martino, S. L. Hofbauer, N. Zamani, S. F. Shariat, and T. Klatte, “Comparison of the prognostic value of pretreatment measurements of systemic inflammatory response in patients undergoing curative resection of clear cell renal cell carcinoma,” World Journal of Urology, vol. 33, no. 12, pp. 2045–2052, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Pichler, G. C. Hutterer, C. Stoeckigt et al., “Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients,” British Journal of Cancer, vol. 108, no. 4, pp. 901–907, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. B. R. Viers, R. H. Thompson, S. A. Boorjian, C. M. Lohse, B. C. Leibovich, and M. K. Tollefson, “Preoperative neutrophil-lymphocyte ratio predicts death among patients with localized clear cell renal carcinoma undergoing nephrectomy,” Urologic Oncology: Seminars and Original Investigations, vol. 32, no. 8, pp. 1277–1284, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Huang, D. M. Dahl, L. Dong et al., “Preoperative neutrophil-to-lymphocyte ratio and neutrophilia are independent predictors of recurrence in patients with localized papillary renal cell carcinoma,” BioMed Research International, vol. 2015, Article ID 891045, 9 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. M. De Martino, A. J. Pantuck, S. Hofbauer et al., “Prognostic impact of preoperative neutrophil-to-lymphocyte ratio in localized nonclear cell renal cell carcinoma,” Journal of Urology, vol. 190, no. 6, pp. 1999–2004, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. R.-M. Wen, Y.-J. Zhang, S. Ma et al., “Preoperative neutrophil to lymphocyte ratio as a prognostic factor in patients with non-metastatic renal cell carcinoma,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 9, pp. 3703–3708, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Forget, J.-P. Machiels, P. G. Coulie et al., “Neutrophil: lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery,” Annals of Surgical Oncology, vol. 20, no. 3, supplement, pp. S650–S660, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. S. P. K. Jagdev, W. Gregory, N. S. Vasudev et al., “Improving the accuracy of pre-operative survival prediction in renal cell carcinoma with C-reactive protein,” British Journal of Cancer, vol. 103, no. 11, pp. 1649–1656, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Luo, D.-L. She, H. Xiong, S.-J. Fu, and L. Yang, “Pretreatment neutrophil to lymphocyte ratio as a prognostic predictor of urologic tumors: a systematic review and meta-analysis,” Medicine, vol. 94, no. 40, article e1670, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. S.-S. Byun, S. K. Hong, S. Lee et al., “The establishment of KORCC (Korean Renal Cell Carcinoma) database,” Investigative and Clinical Urology, vol. 57, no. 1, pp. 50–57, 2016. View at Publisher · View at Google Scholar
  25. F.-M. Deng and J. Melamed, “Histologic variants of renal cell carcinoma: does tumor type influence outcome?” Urologic Clinics of North America, vol. 39, no. 2, pp. 119–132, 2012. View at Publisher · View at Google Scholar · View at Scopus